Pauline Johnson (immunologist)
Pauline Johnson | |
---|---|
Born | Salk Institute |
Known for | Work on lymphocyte cell surface molecules and hyaluronan |
Scientific career | |
Fields | Immunology |
Institutions | University of British Columbia |
Pauline Johnson is an English immunologist and microbiologist at the
Education
Pauline Johnson was born in
Her Ph.D. project was to determine the lateral and rotational mobility of membrane components measured by fluorescence recovery after photobleaching and fluorescence depletion recovery. [3]She was a post-doctoral fellow at the
Salk Institute in California, US under the supervision of Ian Trowbridge and at the MRC Cellular Immunology Unit at the University of Oxford, U.K. under the supervision of Alan F. Williams[4] before joining the faculty at the University of British Columbia in 1991.[2]
Career and research
Johnson helped to establish the function of
tyrosine phosphatase in T cell
activation
[5]
and defined the mechanisms regulating the interactions of the cell adhesion molecule hyaluronan.[6]
Her research in 2020 uses mouse models of lung disease to study the function of
She held an MRC Scientist Award and was Co-Director of the Infection, Inflammation and Immunity Research Group at the Life Science Institute at UBC (2003-2009).CIHR Immunology and Transplantation panel, including as Scientific Officer, as well as on other national and international review panels. She is a member of the CIHR III Institute Advisory Board (III institute = Inflammation, infection and immunity CIHR Institute).[2]
Awards
- MRC Scientist Award, MRC of Canada, 1999-2004
- Women in Science Award for Community Leadership and Scientific Excellence, Minerva Foundation for B.C. Women, 2013[7]
Publications
- Johnson, P. & Garland, P. B. (1981). "Depolarisation of fluorescence depletion. A microscopic method for measuring rotational diffusion of membrane proteins on the surface of a single cell". FEBS Lett. 132 (2): 252–256. PMID 6170530.)
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- Johnson, P. & Williams, A. F. (1986). "Striking similarities between antigen receptor J pieces and sequence in the second chain of the murine CD8 antigen". Nature. 323 (6083): 74–76. S2CID 4305448.)
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- Johnson, P., Ostergaard, H. L., Wasden, C. & Trowbridge, I. S. (1992). "Mutational analysis of CD45, a leukocyte specific tyrosine phosphatase". Journal of Biological Chemistry. 267 (12): 8035–8041. PMID 1314815.)
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- Maiti, A., Maki, G. & Johnson P. (1998). "TNF-α induction of CD44-mediated leukocyte adhesion by sulfation". Science. 282 (5390): 941–943. PMID 9794764.)
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- Ruffell, B., Poon, G.F.T., Lee, S.S.M., Brown, K.L., Tjew, S-L., Cooper. J., & Johnson, P. (2011). "Differential use of chondroitin sulfate to regulate hyaluronan binding by CD44 in inflammatory and alternatively activated macrophages". Journal of Biological Chemistry. 286 (22): 19179–19190. PMID 21471214.)
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- Lee-Sayer, S.M., Dong, Y., Arif, A.A., Olsson, M., Brown, K.L, & Johnson, P. (2015). "The where, when, how, and why of hyaluronan binding by immune cells". Frontiers in Immunology. 6: 150. PMID 25926830.)
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- Samarakoon, A., SHIM, Y. A., Dosanjh, M, Crickmer, M., Labontè-Raymond, C., Arif, A.A. & Johnson, P. (2016). "CD45 regulates GM-CSF, retinoic acid and T cell homing in intestinal inflammation". Mucosal Immunology. 9 (6): 1514–1527. PMID 27007678.)
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- Johnson, P., Arif, AA, Lee-Sayer, S.S.M., Dong, Y. (2018). "Hyaluronan and Its Interactions With Immune Cells in the Healthy and Inflamed Lung". Frontiers in Immunology. 9: 2787. PMID 30555472.)
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- Dong, Y., Arif, AA., Guo, J., HA, Z., Lee-Sayer, SSM., Poon, GFT., Dosanjh, M., Roskelley, C., Huan, T., Johnson, P. (2020). "CD44 loss disrupts lung lipid surfactant homeostasis and exacerbates oxidized lipid-induced lung inflammation". Frontiers in Immunology. 11: 29. PMID 32082314.)
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References
- ^ a b c d "Pauline Johnson | Life Sciences Institute". lsi.ubc.ca.
- ^ a b c d "III Institute Advisory Board Members – Biographies - CIHR". 12 December 2017.
- PMID 6170530.)
{{cite journal}}
: CS1 maint: multiple names: authors list (link - S2CID 35108488.
- PMID 1314815.)
{{cite journal}}
: CS1 maint: multiple names: authors list (link - PMID 9794764.)
{{cite journal}}
: CS1 maint: multiple names: authors list (link - ^ "Announcing the Honourees for Women In™ Science". Minerva BC. 12 November 2013.
External links
- Johnson Lab
- Pauline Johnson publications indexed by Google Scholar