Pentapeptide repeat

Pentapeptide repeat
Structure of the pentapeptide repeat protein HetL.[1]
Identifiers
Symbol	Pentapeptide
Pfam	PF00805
InterPro	IPR001646
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary PDB 2bm4​, 2bm5​, 2bm6​, 2bm7​, 2w7z​, 3du1​, PDB: 2O6W​, PDB: 2J8K​, PDB: 2J8I​

Pentapeptide repeats are a family of sequence motifs found in multiple tandem copies in protein molecules.^[2][3] Pentapeptide repeat proteins are found in all species, but they are found in many copies in cyanobacterial genomes. The repeats were first identified by Black and colleagues in the hglK protein.^[4] The later Bateman et al. showed that a large family of related pentapeptide repeat proteins existed.^[3] The function of these repeats is uncertain in most proteins. However, in the MfpA protein a DNA gyrase inhibitor it has been suggested that the pentapeptide repeat structure mimics the structure of DNA.^[5] The repeats form a regular right handed four sided beta helix structure known as the Rfr-fold.

Sequence features

The pentapeptide repeat is a feature seen in

Pentapeptide repeats were initially predicted from sequence to possess a right handed beta helix with three sides.[3] The first crystal structure of a pentapeptide repeat protein was the MfpA protein solved by Hegde and colleagues. It showed that pentapeptide repeat proteins (PRPs) possessed a four sided beta helix structure.^[5] Four repeats make up one turn of a solenoid like structure. The structures of eight different proteins have been solved to date.

References