HEAT repeat

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1b3u, 1f59, 1gcj, 1ibr, 1m5n, 1o6o, 1o6p, 1qbk, 1qgr, 1u6g, 1ukl, 2bku

HEAT repeat
HEAT repeat
SCOP2	1b3u / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1b3u, 1f59, 1gcj, 1ibr, 1m5n, 1o6o, 1o6p, 1qbk, 1qgr, 1u6g, 1ukl, 2bku

A HEAT repeat is a

armadillo repeats. The nuclear transport protein importin beta

contains 19 HEAT repeats.

Various HEAT repeat proteins and their structures

Representative examples of HEAT repeat proteins include

Ataxia telangiectasia mutated) and ATR (Ataxia telangiectasia and Rad3 related),^[8]^[9] and the microtubule-binding protein XMAP215/Dis1/TOG^[10] and CLASP.^[11]

Thus, cellular functions of HEAT repeat proteins are highly variable.
The structure of the following HEAT repeat proteins have been determined so far:

Protein modification and degradation
A subunit [2] and holoenzyme^[12]^[13] of PP2A

SCFubiquitin ligase regulator Cand1^[14]

Hsm3, a molecular chaperon involved in the assembly of 26Sproteasome^[15]

Nucleo-cytoplasmic transport
Importin β^[16]^[17]^[18]

Exportin Cse1^[19]

Transportin 1^[20]

Nuleoporin Gle1;^[21] Nup188;^[22] Nup192^[23]

Transcriptional regulation
TFIID subunit TAF6^[24]

TBP regulator Mot1 (Modifier of transcription 1)^[25]

Transcriptional initiation factor Rrn3^[26]

Translational regulation
Elongation factor eEF3^[27]

Initiation factor eIF4G^[28]

Aminoacyl tRNA synthetase transfer protein Cex1p^[29]

DNA repair
DNA-PK (DNA-dependent protein kinase)^[30]

Fanconi anemia responsible protein FANCF (FANCF)^[31]

Damaged DNA-binding protein AlkD (Alkylpurin DNA glycosylase)^[32]

PIKKs chaperone Tel2^[33]

Chromosomal regulation
Cohesin subunit SA2^[34]/Scc3^[35]^[36]

Cohesin regulator Wapl^[37]^[38]

Cohesin regulator Pds5^[39]^[40]^[41]

Cohesin loading factor Scc2^[42]^[43]

Cohesin protease Separase^[44]^[45]^[46]

Condensin subunit CAP-G/ycg1^[47]^[48]

Condensin subunit CAP-D2/ycs4^[49]

Cytoskeletal regulation
Microtubule-binding protein TOG^[50]^[51]/Stu2^[52]

Cell proliferation regulation
TOR (
target of rapamycin)^[53]

Others
API5 (Apoptosis inhibitor 5)[54]

V-type ATPase H subunit^[55]

References

S2CID 4408160
.

^
S2CID 14465060
.

PMID 10378263
.

S2CID 6911746
.

PMID 9391096.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 11042144
.

PMID 14712087.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

S2CID 17261901
.

PMID 25460276
.

PMID 11719547
.

PMID 20708587.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

S2CID 18584536.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

S2CID 4408160
.

S2CID 1606360.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 22334676.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

S2CID 4425840.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

S2CID 4413233
.

S2CID 17495979.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

S2CID 4406515
.

PMID 17936704.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 21441902.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 23795296.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 24505056.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 22696218.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 21734658.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 21940764.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

S2CID 14994883.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 11172724.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 23396276.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 20023628.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 17082180.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 20927102.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 20801936.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 25173175.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 25171859.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 30109982.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 23395900.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 23776203.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 26923589.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 26923598.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 26971492.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 27791135.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 28059076.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 27249343.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 28146474
.

PMID 28263324.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 28988770.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 30858338
.

PMID 31226277.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 17355870.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 17889670
.

PMID 22904013.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

S2CID 32663149.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 22334682.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

PMID 11416198.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

External links

Eukaryotic Linear Motif resource motif class LIG_PIKK_1

Eukaryotic Linear Motif resource motif class DOC_PIKK_1

v
t
e
Protein tandem repeats
Fibrous:

Coiled coil

Collagen helix

Elongated:

Alpha solenoid

Ankyrin repeat

Armadillo repeat

Transcription activator-like effector

Beta solenoid

Beta helix

Antifreeze protein

HEAT repeat

Leucine-rich repeat

Pentapeptide repeat

Tetratricopeptide repeat

Trefoil knot fold

Closed:

Beta barrel

Beta trefoil fold

Beta-propeller

Kelch motif

TIM barrel

WD40 repeat

Beads-on-a-string:

Sushi domain

See also:

Repeated sequence (DNA)

Retrieved from "https://en.wikipedia.org/w/index.php?title=HEAT_repeat&oldid=1220911094"

[cho_2006-1] S2CID 4408160
.

[pmid9989501-2] 
S2CID 14465060
.

[3] PMID 10378263
.

[pmid7550332-4] S2CID 6911746
.

[pmid9391096-5] PMID 9391096.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid11042144-6] PMID 11042144
.

[pmid14712087-7] PMID 14712087.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid12553904-8] S2CID 17261901
.

[pmid25460276-9] PMID 25460276
.

[pmid11719547-10] PMID 11719547
.

[pmid20708587-11] PMID 20708587.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid17174897-12] S2CID 18584536.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid17086192-13] S2CID 4408160
.

[pmid15537541-14] S2CID 1606360.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid22334676-15] PMID 22334676.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid10353244-16] S2CID 4425840.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid10353245-17] S2CID 4413233
.

[pmid10929717-18] S2CID 17495979.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid_15602554-19] S2CID 4406515
.

[pmid17936704-20] PMID 17936704.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid21441902-21] PMID 21441902.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid23795296-22] PMID 23795296.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid24505056-23] PMID 24505056.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid22696218-24] PMID 22696218.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid21734658-25] PMID 21734658.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid21940764-26] PMID 21940764.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid16929303-27] S2CID 14994883.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid11172724-28] PMID 11172724.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid23396276-29] PMID 23396276.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid20023628-30] PMID 20023628.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid17082180-31] PMID 17082180.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid20927102-32] PMID 20927102.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid20801936-33] PMID 20801936.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid25173175-34] PMID 25173175.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid25171859-35] PMID 25171859.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid30109982-36] PMID 30109982.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid23395900-37] PMID 23395900.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid23776203-38] PMID 23776203.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid26923589-39] PMID 26923589.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid26923598-40] PMID 26923598.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid26971492-41] PMID 26971492.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid27791135-42] PMID 27791135.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid28059076-43] PMID 28059076.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid27249343-44] PMID 27249343.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid28146474-45] PMID 28146474
.

[pmid28263324-46] PMID 28263324.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid28988770-47] PMID 28988770.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid30858338-48] PMID 30858338
.

[pmid31226277-49] PMID 31226277.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid17355870-50] PMID 17355870.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid17889670-51] PMID 17889670
.

[pmid_22904013-52] PMID 22904013.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid26678875-53] S2CID 32663149.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid22334682-54] PMID 22334682.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

[pmid11416198-55] PMID 11416198.{{cite journal}}: CS1 maint: multiple names: authors list (link
)

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