Perfluorohexane

Source: Wikipedia, the free encyclopedia.
Perfluorohexane
Names
Preferred IUPAC name
Tetradecafluorohexane
Other names
FC-72,
Fluorinert FC-72,
Flutec PP1,
Perfluoro-compound FC-72
Identifiers
3D model (
JSmol
)
Abbreviations PFH
ChEBI
ChemSpider
ECHA InfoCard
 100.005.987 Edit this at Wikidata
KEGG
UNII
  • InChI=1S/C6F14/c7-1(8,3(11,12)5(15,16)17)2(9,10)4(13,14)6(18,19)20 checkY
    Key: ZJIJAJXFLBMLCK-UHFFFAOYSA-N checkY
  • InChI=1/C6F14/c7-1(8,3(11,12)5(15,16)17)2(9,10)4(13,14)6(18,19)20
    Key: ZJIJAJXFLBMLCK-UHFFFAOYAE
  • FC(F)(C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)C(F)(F)F
Properties
C6F14
Molar mass 338.041845
Appearance Clear, colorless
Odor Odorless
Density 1.680 kg/m3 (Liquid)
Melting point −90 °C (−130 °F; 183 K)
Boiling point 56 °C (133 °F; 329 K)
Vapor pressure 30.9 kPa (25 °C)
Thermal conductivity
 0.057 W/(m·K)
Viscosity 0.64 cP
Hazards
NFPA 704 (fire diamond)
NFPA 704 four-colored diamondHealth 0: Exposure under fire conditions would offer no hazard beyond that of ordinary combustible material. E.g. sodium chlorideFlammability 0: Will not burn. E.g. waterInstability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
0
0
0
Lethal dose or concentration (LD, LC):
> 5 g/kg (rat, oral)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)

Perfluorohexane (C6F14), or tetradecafluorohexane, is a fluorocarbon. It is a derivative of hexane in which all the hydrogen atoms are replaced by fluorine atoms. It is used in one formulation of the electronic cooling liquid/insulator Fluorinert for low-temperature applications due to its low boiling point of 56 °C and freezing point of −90 °C. It is odorless and colorless. Unlike typical hydrocarbons, the structure features a helical carbon backbone.[1]

Oxygen solubility

Because it is biologically inert and chemically stable, perfluorohexane has attracted attention in medicine. Like other fluorocarbons, perfluorohexane dissolves gases, including oxygen from the air, to a higher concentration than ordinary organic solvents. This effect is attributed to the weak intermolecular forces between perfluorohexane molecules, which allows "space" for gas molecules to partition into the liquid. Animals can be submerged in a bath of oxygenated perfluorohexane without drowning, as there is sufficient oxygen available in the solvent to allow respiration to continue. This effect has led to the experimental use of perfluorohexane in treating burn victims, as their lungs can be filled with either perfluorohexane vapor or in extreme cases liquid perfluorohexane, allowing breathing to continue without the problems normally seen with pulmonary edema that sometimes occur when the inside of the lungs have been burnt e.g. by inhalation of hot smoke.[2][3] Research was particularly active on the topic of partial liquid ventilation (PLV) in the 1990s and early 2000s, however, perfluorohexane and other perfluorocarbons showed no significant improvement of patient outcomes in clinical trials.[4]

Alternatives

Perfluorohexane has extremely high

Novec 649 was considered a good drop-in replacement in many applications due to its similar thermo-physical properties and having a global warming potential of 1.[5]

See also

References

  1. doi:10.1007/128_2011_282
  2. S2CID 30310674
    .
  3. S2CID 20292926
    .
  4. PMID 16254269
    .
  5. ^ "3M Novec 649 as a replacement of C6F14 in liquid cooling systems" (PDF). CERN. Retrieved April 8, 2021.
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