Peripheral stem cell transplantation

bone marrow harvest equivalent due to the ease and less invasive nature of the procedure.^[3][4] Studies suggest that PBSCT has a better outcome in terms of the number of hematopoietic stem cell (CD34+ cells) yield.^[5]

blood cells.^{[citation needed}

identical twin). The apheresis procedure typically lasts for 4–6 hours, depending on the blood volume of the donor.^[6]

Granulocyte colony stimulating factor (GCSF) are naturally occurring glycoproteins that stimulate white blood cell proliferation. Filgrastim is a synthetic form of GCSF produced in E.coli.^[7] PBSC donors are given a course of GCSF prior to PBSC collection. The increase in white blood cell proliferation as a result of the Filgrastim ensures a better results from the donation. The course is usually given over a 4-day period prior to PBSC collection.^[8] The most common side effects of Filgrastim are bone, joint, back, arm, leg, mouth, throat, and muscle pain.^[9] Additionally, headache, nausea, vomiting, dizziness, fatigue, rash, loss of appetite, and difficulty falling or staying asleep are common.^[9]

autologous PBSCT.^[10]

allogeneic PBSCT.^[11]

1999 Tokaimura nuclear accident. Hisashi Ouchi, who received the highest dose of radiation was treated with PBSCT in an attempt to restore his destroyed immune system. Cells from the patient's sister's bone marrow were administered, and in the following weeks successfully began dividing and differentiating into white blood cells. However, several weeks later, the cells were found to have been mutated by the radiation still present within the patient's body, and were observed carrying out autoimmune responses.^[12] Later studies on the incident and subsequent use of PBSCT found that the transplant had also induced neoendothelialization of the aortic endothelium.^[13]