Polyporic acid

Source: Wikipedia, the free encyclopedia.
Polyporic acid
Names
Preferred IUPAC name
23,26-Dihydroxy[11,21:24,31-terphenyl]-22,25-dione
Other names
Polyporin; Orygameic acid
Identifiers
3D model (
JSmol
)
ChemSpider
MeSH C118527
UNII
  • InChI=1S/C18H12O4/c19-15-13(11-7-3-1-4-8-11)16(20)18(22)14(17(15)21)12-9-5-2-6-10-12/h1-10,19,22H
    Key: HZKFHDXTSAYOSN-UHFFFAOYSA-N
  • InChI=1/C18H12O4/c19-15-13(11-7-3-1-4-8-11)16(20)18(22)14(17(15)21)12-9-5-2-6-10-12/h1-10,19,22H
    Key: HZKFHDXTSAYOSN-UHFFFAOYAL
  • C1=CC=C(C=C1)C2=C(C(=O)C(=C(C2=O)O)C3=CC=CC=C3)O
Properties
C18H12O4
Molar mass 292.290 g·mol−1
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
 Toxic
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Polyporic acid is a para-

inhibits the enzyme dihydroorotate dehydrogenase.[4] It is found in other mushrooms, but in much lower amounts.[4]

In animal studies, consumption of polyporic acid caused reduced locomotor activity, depressed visual placing response, hepatorenal failure, metabolic acidosis, hypokalaemia, and hypocalcaemia.[4] Because these effects are similar to those observed in individuals poisoned by H. nidulans, polyporic acid is thought to be the primary toxin in H. nidulans.[4]

Polyporic acid has some

gamma-lactone antibiotic from the fungus Allantophomopsis lycopodina.[7]

References

  1. doi:10.1002/jlac.18771870204
    .
  2. ISBN 9780444515100. {{cite book}}: |journal= ignored (help
    )
  3. ISBN 978-0-470-74496-3
    .
  4. ^
    S2CID 41488737
    .
  5. PMID 884625
    .
  6. PMID 6541963
    .
  7. S2CID 30217850
    .
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