Polypyrimidine tract

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The essential spliceosome component U2AF bound to a short polypyrimidine RNA fragment.

The polypyrimidine tract is a region of

3' end of the intron to be spliced.[1]

A number of protein factors bind to or associate with the polypyrimidine tract, including the spliceosome component U2AF and the

splice sites.[2] However, PTB binding is not sufficient to suppress "robust" exons.[3]

The suppression or selection of exons is critical to the proper expression of

tissue-specific isoforms. For example, smooth muscle and skeletal muscle express alternate isoforms distinguished by mutually exclusive exon selection in alpha-tropomyosin.[4]

References

  1. ^ Lodish H, Berk A, Matsudaira P, Kaiser CA, Krieger M, Scott MP, Zipursky SL, Darnell J. (2004). Molecular Cell Biology. WH Freeman: New York, NY. 5th ed.
  2. ^ Wagner EJ, Garcia-Blanco MA. (2001). Polypyrimidine tract binding protein antagonizes exon definition. Mol Cell Biol 21(10):3281-3288.
  3. ^ Gooding C, Roberts GC, Smith CW. (1998). Role of an inhibitory pyrimidine element and polypyrimidine tract binding protein in repression of a regulated alpha-tropomyosin exon. RNA 4:85-100.
  4. ^ Gooding C, Roberts GC, Moreau G, Nadal-Ginard B, Smith CW. (1994). Smooth muscle-specific switching of alpha-tropomyosin mutually exclusive exon selection by specific inhibition of the strong default exon. EMBO J 13(16):3861-72.
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