Protein Information Resource

Source: Wikipedia, the free encyclopedia.

The Protein Information Resource (PIR), located at Georgetown University Medical Center, is an integrated public bioinformatics resource to support genomic and proteomic research, and scientific studies. It contains protein sequences databases [1][2][3][4][5][6][7]

History

PIR was established in 1984 by the National Biomedical Research Foundation as a resource to assist researchers and customers in the identification and interpretation of

Margaret Dayhoff. Dayhoff and her research group pioneered in the development of computer methods for the comparison of protein sequences, for the detection of distantly related sequences and duplications within sequences, and for the inference of evolutionary histories from alignments of protein sequences.[8]

Winona Barker and Robert Ledley assumed leadership of the project after the death of Dayhoff in 1983. In 1999, Cathy H. Wu joined the National Biomedical Research Foundation, and later on Georgetown University Medical Center, to head the bioinformatics efforts of PIR, and has served first as Principal Investigator and, since 2001, as Director.[citation needed]

For four decades, PIR has provided many protein databases and analysis tools freely accessible to the scientific community, including the Protein Sequence Database, the first international database (see PIR-International), which grew out of Atlas of Protein Sequences and Structure.[citation needed]

In 2002, PIR – along with its international partners, the

TrEMBL databases. As of 2010, PIR offers a wide variety of resources mainly oriented to assist the propagation and standardization of protein annotation: PIRSF,[9]
iProClass, and iProLINK.

The Protein Ontology is another popular database released by the Protein Information Resource.[10][11]

References

  1. ^ http://pir.georgetown.edu/ Archived 2014-03-12 at the Wayback Machine Official website of PIR at Georgetown University.
  2. PMID 15588483
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  8. ^ Izet, M (2016). "The Most Influential Scientists in the Development of Medical informatics (13): Margaret Belle Dayhoff". Acta Inform Med. 24 (4).
  9. PMID 14681371
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  10. ^ "GeorgeTown.edu - Protein Ontology". Archived from the original on 2011-03-10. Retrieved 2017-12-04.
  11. S2CID 66974875
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