RBM3
| RBM3 | |||
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Gene ontology | |||
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| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl |
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| UniProt |
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| RefSeq (protein) |
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| Location (UCSC) | Chr X: 48.57 – 48.58 Mb | n/a | |||||||
| PubMed search | [2] | [3] | |||||||
| View/Edit Human | View/Edit Mouse |
Putative RNA-binding protein 3 is a protein that in humans is encoded by the RBM3 gene.[4][5]
Function
This gene is a member of the
isoforms, have been characterized.[5]
RBM3 is cold-induced RNA binding protein and is involved in mRNA biogenesis exerts anti-
apoptotic effects.[6] According to antibody-based profiling and transcriptomics analysis, RBM3 protein is present in all analysed human tissues[7] and based on confocal microscopy mainly localised to the nucleoplasm.[8]
Clinical significance
RBM3 is a
proto-oncogene that is associated with tumor progression and metastasis and is a potential cancer biomarker.[6] Based on patient survival data, high levels of RBM3 protein in tumor cells is a favourable prognostic biomarker in colorectal cancer.[9]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000102317 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 8634703.
- ^ a b "Entrez Gene: RBM3 RNA binding motif (RNP1, RRM) protein 3".
- ^ PMID 28118608.
- ^ "Tissue expression of RBM3 - Summary". The Human Protein Atlas.
- ^ "Cell atlas - RBM3". The Human Protein Atlas.
- ^ "Expression of RBM3 in cancer - Summary". The Human Protein Atlas.
Further reading
- Danno S, Nishiyama H, Higashitsuji H, Yokoi H, Xue JH, Itoh K, Matsuda T, Fujita J (July 1997). "Increased transcript level of RBM3, a member of the glycine-rich RNA-binding protein family, in human cells in response to cold stress". Biochemical and Biophysical Research Communications. 236 (3): 804–7. PMID 9245737.
- Chappell SA, Mauro VP (September 2003). "The internal ribosome entry site (IRES) contained within the RNA-binding motif protein 3 (Rbm3) mRNA is composed of functionally distinct elements". The Journal of Biological Chemistry. 278 (36): 33793–800. PMID 12824175.
- Wellmann S, Bührer C, Moderegger E, Zelmer A, Kirschner R, Koehne P, Fujita J, Seeger K (April 2004). "Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism". Journal of Cell Science. 117 (Pt 9): 1785–94. PMID 15075239.
- Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. PMID 15144186.
- Dellis S, Strickland KC, McCrary WJ, Patel A, Stocum E, Wright CF (November 2004). "Protein interactions among the vaccinia virus late transcription factors". Virology. 329 (2): 328–36. PMID 15518812.
- Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. S2CID 4344740.
- Ong SE, Mittler G, Mann M (November 2004). "Identifying and quantifying in vivo methylation sites by heavy methyl SILAC". Nature Methods. 1 (2): 119–26. S2CID 6654604.
- Martínez-Arribas F, Agudo D, Pollán M, Gómez-Esquer F, Díaz-Gil G, Lucas R, Schneider J (April 2006). "Positive correlation between the expression of X-chromosome RBM genes (RBMX, RBM3, RBM10) and the proapoptotic Bax gene in human breast cancer". Journal of Cellular Biochemistry. 97 (6): 1275–82. S2CID 9804734.
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