RBP3
| RBP3 | |||
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Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 10: 47.35 – 47.36 Mb | Chr 14: 33.68 – 33.69 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Retinol-binding protein 3, interstitial (RBP3), also known as interphotoreceptor retinoid-binding protein (IRBP), is a
Function
The inter-photoreceptor retinoid-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium (RPE) and the photoreceptor cells. It is thought to transport retinoids between the RPE and the photoreceptors, a critical role in the visual process.[8][9]
Gene
The human IRBP gene is approximately 9.5 kbp in length and consists of four
Structure
The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively.[5]
Application
The rbp3 gene is commonly used in animals as a
Note that the RBP3 intron 1 has also been used to investigate the
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000265203 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041534 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: RBP3 retinol binding protein 3, interstitial".
- ^ a b "OrthoMaM phylogenetic marker: RBP3 gene, exon 1".[permanent dead link]
- PMID 37036996.
- . Retrieved 11 Apr 2023.
- PMID 19720652.
- PMID 1342928.
- S2CID 25865281.
- S2CID 4398233.
- PMID 12082125.
- PMID 12821774.
- PMID 15085543.
- PMID 15019624.
- PMID 18245770.
- .
- S2CID 38824060.
- S2CID 21422211.
- PMID 8771309.
Further reading
- Fong SL, Fong WB, Morris TA, Kedzie KM, Bridges CD (Mar 1990). "Characterization and comparative structural features of the gene for human interstitial retinol-binding protein". The Journal of Biological Chemistry. 265 (7): 3648–53. PMID 2303470.
- Albini A, Toffenetti J, Zhu Z, Chader GJ, Noonan DM (Sep 1990). "Hypomethylation of the interphotoreceptor retinoid-binding protein (IRBP) promotor and first exon is linked to expression of the gene". Nucleic Acids Research. 18 (17): 5181–7. PMID 2402443.
- Liou GI, Ma DP, Yang YW, Geng L, Zhu C, Baehr W (May 1989). "Human interstitial retinoid-binding protein. Gene structure and primary structure". The Journal of Biological Chemistry. 264 (14): 8200–6. PMID 2542268.
- Si JS, Borst DE, Redmond TM, Nickerson JM (Aug 1989). "Cloning of cDNAs encoding human interphotoreceptor retinoid-binding protein (IRBP) and comparison with bovine IRBP sequences". Gene. 80 (1): 99–108. S2CID 34897302.
- Nakamura Y, Lathrop M, Bragg T, Leppert M, O'Connell P, Jones C, Lalouel JM, White R (Nov 1988). "An extended genetic linkage map of markers for human chromosome 10". Genomics. 3 (4): 389–92. PMID 2907505.
- Fong SL, Bridges CD (Oct 1988). "Internal quadruplication in the structure of human interstitial retinol-binding protein deduced from its cloned cDNA". The Journal of Biological Chemistry. 263 (30): 15330–4. PMID 3170584.
- Liou GI, Fong SL, Gosden J, van Tuinen P, Ledbetter DH, Christie S, Rout D, Bhattacharya S, Cook RG, Li Y (Jul 1987). "Human interstitial retinol-binding protein (IRBP): cloning, partial sequence, and chromosomal localization". Somatic Cell and Molecular Genetics. 13 (4): 315–23. S2CID 20206120.
- Fong SL, Cook RG, Alvarez RA, Liou GI, Landers RA, Bridges CD (Sep 1986). "N-terminal sequence homologies in interstitial retinol-binding proteins from 10 vertebrate species". FEBS Letters. 205 (2): 309–12. S2CID 45787370.
- Redmond TM, Wiggert B, Robey FA, Chader GJ (Nov 1986). "Interspecies conservation of structure of interphotoreceptor retinoid-binding protein. Similarities and differences as adjudged by peptide mapping and N-terminal sequencing". The Biochemical Journal. 240 (1): 19–26. PMID 3827838.
- Chen Y, Houghton LA, Brenna JT, Noy N (Aug 1996). "Docosahexaenoic acid modulates the interactions of the interphotoreceptor retinoid-binding protein with 11-cis-retinal". The Journal of Biological Chemistry. 271 (34): 20507–15. PMID 8702792.
- Shaw NS, Noy N (Feb 2001). "Interphotoreceptor retinoid-binding protein contains three retinoid binding sites". Experimental Eye Research. 72 (2): 183–90. PMID 11161734.
- Foltz DR, Nye JS (Aug 2001). "Hyperphosphorylation and association with RBP of the intracellular domain of Notch1". Biochemical and Biophysical Research Communications. 286 (3): 484–92. PMID 11511084.
- Howard OM, Dong HF, Su SB, Caspi RR, Chen X, Plotz P, Oppenheim JJ (Jun 2005). "Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate". Blood. 105 (11): 4207–14. PMID 15713799.