SABRE Research UK

SABRE Research UK
Predecessor	Society for Accountability of Animal Studies in Biomedical Research and Education
Formation	5 December 2005
Dissolved	13 May 2019
Type	systematic reviews of animal studies to determine the value of animal research to human health.
Location	United Kingdom;
Official language	English

SABRE Research UK was a British

animal research

. It addressed issues in

polarised positions in the debate about animal research.^[1]

The charity reported that neither the proponents of animal research nor its opponents were able to produce sufficiently sound scientific evidence in support of their opposing cases.

The charity was independent from

clinical trials

.

History

The formation of the charity followed the publication of an Education and Debate paper in the

randomised controlled clinical trials. These measures are considered important as they promote higher standards of research conduct through higher reporting standards.^[2]

In 2005 a report was published by the

MRC, the Biotechnology and Biological Sciences Research Council (BBSRC), animal protection groups and industry associations such as the Association of the British Pharmaceutical Industry

(ABPI)’.

A larger study was published in the BMJ in 2007 which drew attention to a lack of communication between animal researchers and clinical researchers and 'identified a gap in knowledge about the usefulness of the volume of animal studies that look at biological mechanisms of disease' and that 'more systematic reviews are needed for a quantitative appraisal of the concordance between animal and clinical trials.' The review reiterated earlier calls for the Home Office to undertake prospective registration of animal studies. The authors had found that the Home Office showed a lack of interest in the quality of record-keeping needed for preparing systematic reviews.[4]

SABRE's priorities for research involving animals

Implementation of the 10Rs+ Strategy to include a full programme of
Systematic reviews of existing animal studies before funding any new animal research. http://bmcmedethics.biomedcentral.com/articles/10.1186/s12910-015-0043-7

Prospective registration of animal studies (to be maintained by the Home Office) with adequate details recorded to inform subsequent systematic reviews.
Adoption and implementation of the new guidelines (The ARRIVE Guidelines) on reporting animal research, by authors, journal editors, peer reviewers, and funding bodies.
A large-scale programme of systematic reviews of existing animal studies (the published results of laboratory animal experiments) to be conducted to assess and monitor the value of animal research to the promotion of human health.

References

^ "SABRE RESEARCH UK - Charity 1112399". register-of-charities.charitycommission.gov.uk. Retrieved 2022-06-10.
^ Pound P. et al. Where is the evidence that animal research benefits humans? BMJ. 2004 Feb 28;328(7438):514-7.
^ Nuffield Council on Bioethics. The ethics of research involving animals. 2005 http://www.nuffieldbioethics.org/animal-research
^ Perel P. et al, Comparison of treatment effects between animal experiments and clinical trials: systematic review. BMJ 2007

External links

Official website

[1] "SABRE RESEARCH UK - Charity 1112399". register-of-charities.charitycommission.gov.uk. Retrieved 2022-06-10.

[2] Pound P. et al. Where is the evidence that animal research benefits humans? BMJ. 2004 Feb 28;328(7438):514-7.

[3] Nuffield Council on Bioethics. The ethics of research involving animals. 2005 http://www.nuffieldbioethics.org/animal-research

[4] Perel P. et al, Comparison of treatment effects between animal experiments and clinical trials: systematic review. BMJ 2007

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