SMCR7L

MIEF1
Available structures
Gene ontology
Molecular function	nucleotide binding; ADP binding; protein binding; GDP binding; identical protein binding;
Cellular component	integral component of membrane; mitochondrial outer membrane; peroxisome; membrane; mitochondrion; mitochondrial matrix; mitochondrial large ribosomal subunit;
Biological process	mitochondrial fusion; positive regulation of mitochondrial fission; mitochondrial fission; positive regulation of protein targeting to membrane; regulation of translation; ribosome biogenesis; positive regulation of mitochondrial translation;
	Sources:Amigo / QuickGO
	ENSG00000100335
	ENSMUSG00000022412
	L0R8F8
	Q8BGV8
	NM_001304564; NM_013298; NM_019008; NM_001394030
	NM_178719; NM_001357659; NM_001357660
	NP_001291493; NP_061881
	NP_848834; NP_001344588; NP_001344589
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial dynamic protein MID51 (MID51) also known as mitochondrial elongation factor 1 (MIEF1) or Smith-Magenis syndrome chromosome region candidate gene 7 protein-like (SMCR7L) is a protein that in humans is encoded by the SMCR7L gene.^[5]^[6]^[7]

Function

The SMCR7L gene codes for a protein that has been called MiD51/MIEF1 and shown to regulate mitochondrial fission by interacting with the proteins Drp1 and FIS1.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100335 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022412 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
PMID 11230166
.

PMID 8619474
.

^ "Entrez Gene: SMCR7L Smith-Magenis syndrome chromosome region, candidate 7-like".

PMID 21772324
.

Further reading

Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8.
PMID 9110174
.

Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95.
PMID 10591208
.

Hartley JL; Temple GF; Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95.
PMID 11076863
.

Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92.
PMID 11256614
.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
PMID 12477932
.

Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50.
S2CID 2371325
.

Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44.
PMID 15489336
.

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8.
S2CID 4427026
.

Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8.
PMID 16381901
.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.
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Retrieved from "https://en.wikipedia.org/w/index.php?title=SMCR7L&oldid=1136296581"

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100335 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022412 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11230166-5] PMID 11230166
.

[pmid8619474-6] PMID 8619474
.

[entrez-7] "Entrez Gene: SMCR7L Smith-Magenis syndrome chromosome region, candidate 7-like".

[8] PMID 21772324
.

[3]

[4]

[5]

[6]

[7]

[8]