SNX27

SNX27
Available structures
Gene ontology
Molecular function	phosphatidylinositol-3-phosphate binding; protein binding; phosphatidylinositol binding; lipid binding;
Cellular component	early endosome membrane; membrane; nucleoplasm; retromer complex; early endosome; immunological synapse; WASH complex; cytoplasm; endosome; cytosol;
Biological process	establishment of natural killer cell polarity; endosome to lysosome transport; endosomal transport; protein transport; intracellular protein transport; signal transduction;
	Sources:Amigo / QuickGO
	ENSG00000143376
	ENSMUSG00000028136
	Q96L92
	Q3UHD6
	NM_030918; NM_001330723
	NM_001082484; NM_029721
	NP_001317652; NP_112180
	NP_001075953; NP_083997
	Wikidata
View/Edit Human	View/Edit Mouse

Sorting nexin family member 27, also known as SNX27, is a human gene.^[5]

This gene encodes a member of the

phosphoinositide binding domain (PX domain). A highly similar protein in mice is responsible for the specific recruitment of an isoform of the serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143376 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028136 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: SNX27 sorting nexin family member 27".

Joubert L, Hanson B, Barthet G, Sebben M, Claeysen S, Hong W, Marin P, Dumuis A, Bockaert J (October 2004). "New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting". Journal of Cell Science. 117 (Pt 22): 5367–79.
PMID 15466885
.

Rincón E, Santos T, Avila-Flores A, Albar JP, Lalioti V, Lei C, Hong W, Mérida I (June 2007). "Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling". Molecular & Cellular Proteomics. 6 (6): 1073–87.
PMID 17351151
.

MacNeil AJ, Mansour M, Pohajdak B (August 2007). "Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes". Biochemical and Biophysical Research Communications. 359 (4): 848–53.
PMID 17577583
.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143376 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028136 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SNX27 sorting nexin family member 27".

[3]

[4]

[5]

v t e Sorting nexins
SNX-BAR	SNX1 SNX2 SNX4 SNX5 SNX6 SNX7 SNX8 SNX9 SNX18 SNX30 SNX32 SNX33
SNX-PX	SNX3 SNX10 SNX11 SNX12 SNX16 SNX20 SNX21 SNX22 SNX24 SNX29
SNX-Other	SNX13 SNX14 SNX15 SNX17 SNX19 SNX23 SNX25 SNX26 SNX27 SNX28 SNX31
Related articles	PX domain BAR domain Retromer

References

Further reading