STEAP2
| STEAP2 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
| View/Edit Human | View/Edit Mouse |
Metalloreductase STEAP2 is an enzyme that in humans is encoded by the STEAP2 gene.[5][6][7]
This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the
Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol
.
A highly similar protein in mouse has both ferri reductase and cupric
isoforms, have been characterized.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000157214 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015653 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 10613842.
- PMID 12095985.
- ^ a b "Entrez Gene: STEAP2 six transmembrane epithelial antigen of the prostate 2".
Further reading
- Denoeud F, Kapranov P, Ucla C, et al. (2007). "Prominent use of distal 5′ transcription start sites and discovery of a large number of additional exons in ENCODE regions". Genome Res. 17 (6): 746–59. PMID 17567994.
- Ohgami RS, Campagna DR, McDonald A, Fleming MD (2006). "The Steap proteins are metalloreductases". Blood. 108 (4): 1388–94. PMID 16609065.
- Korkmaz CG, Korkmaz KS, Kurys P, et al. (2005). "Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer". Oncogene. 24 (31): 4934–45. PMID 15897894.
- Sanchez-Pulido L, Rojas AM, Valencia A, et al. (2005). "ACRATA: a novel electron transfer domain associated to apoptosis and cancer". BMC Cancer. 4: 98. PMID 15623366.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. PMID 12975309.
- Porkka KP, Helenius MA, Visakorpi T (2002). "Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate". Lab. Invest. 82 (11): 1573–82. PMID 12429817.
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