Shroom protein family
| ASD1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | ASD1 | ||||||||
| Pfam | PF08688 | ||||||||
| InterPro | IPR014800 | ||||||||
| |||||||||
| ASD2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | ASD2 | ||||||||
| Pfam | PF08687 | ||||||||
| InterPro | IPR014799 | ||||||||
| |||||||||
In molecular biology, the Shroom protein family is a small group of related
mice and humans, the Shrm family of proteins
consists of:
- Shrm2 (formerly Apxl), a protein involved in the morphogenesis, maintenance, and/or function of vascular endothelial cells.
- Shrm3 (formerly Shroom), a protein necessary for neural tube closure in vertebrate development as deficiency in Shrm results in spina bifida. Shrm3 is also conserved in some invertebrates, as orthologues can be found in sea urchins.
- Shrm4, a regulator of cyto-skeletal architecture that may play an important role in vertebrate development. It is implicated in X-linked humans.
This protein family is based on the
conserved series of leucine residues that exhibit spacing consistent with that of a leucine zipper motif.[1]
Shroom2 is both necessary and sufficient to govern the localization of pigment granules at the
mutations may contribute to human visual system disorders.[4]