Sintilimab

Source: Wikipedia, the free encyclopedia.
Sintilimab
Monoclonal antibody
Type?
Clinical data
Other namesAnti-PD-1 monoclonal antibody IBI308[1]
Identifiers
CAS Number
UNII
KEGG

Sintilimab, sold under the brand Tyvyt among others, is a medication used to treat

China.[3]

It is a fully

It was jointly developed by Innovent Biologics[6] and Eli Lilly.[7]

Medical uses

Sintilimab is medication that is indicated for the treatment of relapsed or refractory classical

Hodgkin's lymphoma[8] after failure of at least second-line systemic chemotherapy.[5]

Side effects

Common side effects include

thyroid dysfunction, elevation of liver enzymes, and lung inflammation.[9]

Research

Currently, more than 20

monotherapy or in combination with other agents, on a variety of solid tumors.[10] In January 2019, the result of the registration trial of sintilimab in people with refractory or relapsed classical Hodgkin's lymphoma was published.[8]

References

  1. ^ "anti-PD-1 monoclonal antibody IBI308". NCI Drug Dictionary. National Cancer Institute. 2011-02-02.
  2. ^ "Antibody Drug Conjugates Market Growth Forecast Analysis by Manufacturers, Regions, Type and Application to 2026". Reuters. October 24, 2018.
  3. Asian Scientist Magazine
    . January 9, 2019.
  4. . Retrieved Dec 1, 2018.
  5. ^ .
  6. SEC.gov
    . December 20, 2018.
  7. ^ "Sintilimab - Eli Lilly/Innovent Biologics". Adis Insight. Springer Nature Switzerland AG. 28 March 2019.
  8. ^
    S2CID 58561198
    .
  9. ^ A first-in-human phase 1a trial of sintilimab (IBI308). 2018 ASCO Annual Meeting. American Society of Clinical Oncology. 12 October 2019.
  10. ^ Innovent Biologics, Inc. "Innovent Organized a Forum Discussing the Pending Launch of its Anti PD-1 Tyvyt® (Sintilimab injection)". PR NewsWire (Press release). Retrieved Feb 22, 2019.