Spitz nevus

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Spitz nevus
Spitz nevus
SpecialtyOncology, Dermatology
Prognosisbenign

A Spitz nevus is a

epidermis and dermis.[1]

It is also known as an epithelioid and spindle-cell nevus,[2] and misleadingly as a benign juvenile melanoma,[2]: 691  and Spitz's juvenile melanoma[3]). The name juvenile melanoma is generally no longer used as it is neither a melanoma, nor does it occur only in children.[4]

Pathophysiology

Micrograph of a Spitz nevus showing the characteristic vertically arranged nests of cells ("hanging bananas"). H&E stain.

The cause of Spitz nevi is not yet known. There is an association with

chromosome 11 (11p).[1]

Diagnosis

Various differential diagnoses of pigmented skin lesions, by relative incidence and malignancy potential, including "Spitz, Reed or spindle nevus" at top right.

On

malignant melanoma
.

Treatment

Surgical removal is usually performed, even though it is benign.[citation needed]

Epidemiology

Spitz nevi are uncommon. Their annual

sub-tropical Queensland to be 1.4 cases per 100,000 people. For comparison, the annual incidence of melanoma in the same population, which is high by world standards[5] is 25.4 cases per 100,000 people.[4]

Although they are most commonly found on people in their first two decades of life,[1] the age range for people with Spitz nevi is from 6 months to 71 years, with a mean age of 22 years and a median age of 19 years.[4]

Eponym

The lesion is named after Sophie Spitz, the pathologist who originally described it in 1948.[6]

See also

References

  1. ^ a b c d LeBoit, PE, Burg G, Weedon D, Sarasin A. (Eds) World Health Organization Classification of Tumours: Pathology and Genetics of Skin Tumours. Lyon: IARCPress. 2006.
  2. ^ .
  3. .
  4. ^ a b c Crotty, K. Spitz Naevus: Histological features and distinction from malignant melanoma. Australasian Journal of Dermatology. 38 (suppl): S49-S53. 1997.
  5. ^ Ries LAG, et al., eds. SEER Cancer Statistics Review, 1975–2000. Bethesda, MD: National Cancer Institute; 2003: Tables XVI-1-9.
  6. ^ Spitz S. Melanomas of childhood. Am. J. Pathol.1948;24:591-609.

External links