Splicing factor

Source: Wikipedia, the free encyclopedia.

A splicing factor is a protein involved in the removal of

spliceosomes. Genes are progressively switched off as people age, and splicing factors can reverse this trend.[1] Splicing factors regulate the binding of the snRNPs U1 and U2 to the 3' and 5' ends of the intron during splicing and can either be splicing promoters or splicing repressors.[2]

In a research paper, splicing factors were found to be produced upon application of resveratrol analogues, which induced senescent cells to rejuvenate.[1]

Notes

  1. ^ a b "Old human cells rejuvenated in breakthrough discovery on ageing".
  2. PMID 18369186
    .