Stollé synthesis

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The Stollé synthesis is a series of chemical reactions that produce oxindoles from anilines and α-haloacid chlorides (or oxalyl chloride).[1][2][3][4]

The Stollé synthesis
The Stollé synthesis

The first step is an amide coupling, while the second step is a Friedel–Crafts reaction.[5][6] An improved procedure has been developed.[7][8]

See also

References

  1. doi:10.1002/cber.191304603186
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  2. doi:10.1002/cber.191404702112
    .
  3. doi:10.1002/prac.19221050111
    .
  4. doi:10.1002/prac.19301280101
    .
  5. doi:10.1021/cr60109a003
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  6. PMID 21013427
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  7. doi:10.1021/ja01306a053
    .
  8. doi:10.15227/orgsyn.030.0062
    ; Collected Volumes, vol. 4, p. 620.
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