T-cell receptor excision circles

Edit links
Source: Wikipedia, the free encyclopedia.

T-cell receptor excision circles (TRECs) are small circles of

T-cells during their passage through the thymus as they rearrange their TCR genes.[1]
Their presence indicates maturation of T cells; TRECs are reduced in SCID (severe combined immunodeficiency disease).

Signal joint T-cell receptor excision circles (sjTRECs) might be used as a way to test the age of the individual from a blood sample.[2] The detection of sjTRECs can be further used as a diagnostic tool to monitor the thymic output (e.g., following hematopoietic stem cell transplantation or in cases of AIDS).[3]

See also

References

  1. ^ http://allergycases.org/2010/05/t-cell-receptor-excision-circles-trecs.html[full citation needed]
  2. PMID 22365662
    .
  3. PMID 10725462
    .
Stub icon

This genetics article is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=T-cell_receptor_excision_circles&oldid=1195192660"