TMEM158
| TMEM158 | ||||||
|---|---|---|---|---|---|---|
| Identifiers | ||||||
Ensembl | ||||||
| UniProt | ||||||
| RefSeq (mRNA) | ||||||
| RefSeq (protein) | ||||||
| Location (UCSC) | Chr 3: 45.22 – 45.23 Mb | Chr 9: 123.09 – 123.09 Mb | ||||
| PubMed search | [3] | [4] | ||||
| View/Edit Human | View/Edit Mouse |
Transmembrane protein 158 is a protein that in humans is encoded by the TMEM158 gene.[5][6][7]
Constitutive activation of the
Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence.
Transcription of this gene is upregulated in response to activation of the Ras pathway, but not under other conditions that induce senescence.
The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000249992 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054871 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 11399754.
- PMID 11822868.
- ^ a b "Entrez Gene: TMEM158 transmembrane protein 158".
Further reading
- Iglesias D, Fernández-Peralta AM, Nejda N, et al. (2006). "RIS1, a gene with trinucleotide repeats, is a target in the mutator pathway of colorectal carcinogenesis". Cancer Genet. Cytogenet. 167 (2): 138–44. PMID 16737913.
- Zirn B, Samans B, Wittmann S, et al. (2006). "Target genes of the WNT/beta-catenin pathway in Wilms tumors". Genes Chromosomes Cancer. 45 (6): 565–74. S2CID 84406946.
- Silva J, Silva JM, Barradas M, et al. (2006). "Analysis of the candidate tumor suppressor Ris-1 in primary human breast carcinomas". Mutat. Res. 594 (1–2): 78–85. PMID 16280139.
- Sussan TE, Pletcher MT, Murakami Y, Reeves RH (2006). "Tumor suppressor in lung cancer 1 (TSLC1) alters tumorigenic growth properties and gene expression". Mol. Cancer. 4: 28. PMID 16083501.
- Verlinden I, Janssens J, Raus J, Michiels L (2005). "Microdissection and SAGE as a combined tool to reveal gene expression in ductal carcinoma in situ of the breast". Mol. Carcinog. 41 (4): 197–206. S2CID 19850341.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.