TPM4

TPM4
Identifiers
Gene ontology
Molecular function	calcium ion binding; actin binding; structural constituent of muscle; protein binding; metal ion binding; identical protein binding; protein homodimerization activity; protein heterodimerization activity; actin filament binding;
Cellular component	cytoplasm; filamentous actin; podosome; cytosol; muscle thin filament tropomyosin; cortical cytoskeleton; extracellular exosome; cytoskeleton; membrane; stress fiber; focal adhesion; actin filament; actin cytoskeleton;
Biological process	osteoblast differentiation; muscle filament sliding; muscle contraction; actin filament organization;
	Sources:Amigo / QuickGO

Ensembl


ENSG00000167460


n/a

UniProt


P67936


n/a

RefSeq (mRNA)


NM_001145160 NM_003290 NM_001367836 NM_001367837 NM_001367838


n/a

RefSeq (protein)


NP_001138632 NP_003281 NP_001354765 NP_001354766 NP_001354767


n/a

Location (UCSC)

Chr 19: 16.07 – 16.1 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Tropomyosin alpha-4 chain is a protein that in humans is encoded by the TPM4 gene.^[3]^[4]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167460 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
PMID 8641132
.

^ "Entrez Gene: TPM4 tropomyosin 4".

Further reading

Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9.
S2CID 41855774
.

MacLeod AR, Talbot K, Smillie LB, Houlker C (1987). "Characterization of a cDNA defining a gene family encoding TM30p1, a human fibroblast tropomyosin". J. Mol. Biol. 194 (1): 1–10.
PMID 3612796
.

MacLeod AR, Houlker C, Reinach FC, et al. (1986). "A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism". Proc. Natl. Acad. Sci. U.S.A. 82 (23): 7835–9.
PMID 3865200
.

Lawrence B, Perez-Atayde A, Hibbard MK, et al. (2000). "TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors". Am. J. Pathol. 157 (2): 377–84.
PMID 10934142
.

Meech SJ, McGavran L, Odom LF, et al. (2001). "Unusual childhood extramedullary hematologic malignancy with natural killer cell properties that contains tropomyosin 4--anaplastic lymphoma kinase gene fusion". Blood. 98 (4): 1209–16.
PMID 11493472
.

Yi J, Kloeker S, Jensen CC, et al. (2002). "Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers". J. Biol. Chem. 277 (11): 9580–9.
PMID 11782456
.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
PMID 12477932
.

Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9.
S2CID 23783563
.

Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5.
PMID 14702039
.

Lin KT, Lu RM, Tarn WY (2004). "The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo". Mol. Cell. Biol. 24 (20): 9176–85.
PMID 15456888
.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7.
PMID 15489334
.

Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84.
S2CID 26007149
.

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8.
S2CID 4427026
.

v
t
e

Retrieved from "https://en.wikipedia.org/w/index.php?title=TPM4&oldid=1113086361"

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167460 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8641132-3] PMID 8641132
.

[entrez-4] "Entrez Gene: TPM4 tropomyosin 4".

[2]

[3]

[4]