Talk:Amyloid-beta precursor protein
A fact from Amyloid-beta precursor protein appeared on Wikipedia's Main Page in the Did you know column on 29 January 2007. The text of the entry was as follows:
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Holy cow. I am impressed. A five eyed genius !--Filll 03:30, 29 January 2007 (UTC)
- Thanks ;) I don't know about this one, but I hope to make amyloid beta an FA eventually. Opabinia regalis 06:08, 31 January 2007 (UTC)
this article might give more information on what app does:
NeuroRx: THe Journal of the American Society for experimental NeuroTherapeutics (2005) Vol. 2, 612-626 01:56, 4 April 2007 (UTC)ashok
Gamma-secretase
Gamma-secretase is now much more fully understood than this article indicates. presenillin 1 forms the core of the enzyme, but yeast two hybrid assays have shown interactions with several other proteins and nicastrin, Aph1A and PEN2 have been shown to be critical for gamme secretease activity. I will do the proper edit when I get some time. Povmcdov 14:32, 14 April 2007 (UTC)
- The gamma secretase article has that information. This article does say gamma secretase is "a large multi-subunit complex whose components have not yet been fully characterized, but notably include presenilin, whose gene has been identified as a major genetic risk factor for Alzheimer's." I think it's fine as is. Flyguy649talkcontribs 14:46, 14 April 2007 (UTC)
Formatting help?
Just noticed that my previous change to add an updated protein infobox (using
Up-regulated has a hyphen
Or am I out-dated? —Preceding unsigned comment added by 201.9.218.149 (talk) 21:31, 17 February 2008 (UTC)
Sexual Behavoir
Amyloid precursor protein regulates libido in experimental rats[1]
Difference between APP and prion
They are both part of amyloidosis. They both bind copper. Can anybody tell me the difference between PrP and APP? 137.186.47.81 (talk) 10:40, 8 March 2012 (UTC)
- The amyloidoses are a family of diseases with one pathological feature in common: the presence of beta amyloid and the protein PrP can both form amyloid deposits (beta amyloid in Alzheimer's disease, PrP in mammalian prion disease) that doesn't mean that both proteins are the same. By analogy, brick and wood can both be used to make houses, but that doesn't mean that brick and wood are the same material. TenOfAllTrades(talk) 16:35, 8 March 2012 (UTC)]
- It's very simple. A protein is defined by its amino acid sequence. APP and PrP are the names for two proteins, that have totally different amino acid sequences. Joannamasel (talk) 15:59, 8 March 2012 (UTC)
- All that the prion article specifiez iz statistics on the bonding and molecular weight of a protein that can become protease resistant. Please avoid abbreviations. An earlier version of the document on protease resistant protein noted that prion was often found in amyloid fibres, and that Alzheimer's was a prion disease. It went on to define spiroid protein az normal, and sheet protein az diseased (ignoring a third barrel conformation that protease resistant protein can take). That turned out to be defective theory, as Brown showed that the presence of Manganese made prion mostly into a spiroid, while copper made it mostly into a sheet.[2] Both proteins bind copper. Iz one part of the other? Or are they both merely found in amyloidosis.
"The plaques are composed of a tangle of regularly ordered fibrillar aggregates called amyloid fibers,
Okay, so finally I got PrP, as different from prion. HAH! That's retarded, and yet I sit corrected. 137.186.47.81 (talk) 17:19, 9 March 2012 (UTC)