Taxadiene

Source: Wikipedia, the free encyclopedia.
Taxadiene
Names
IUPAC name
Taxa-4,11-diene
Systematic IUPAC name
(4aS,6S,12aS)-4,9,12a-Trimethyl-1,2,4a,5,6,7,8,11,12,12a-decahydro-6,10-methanobenzo[10]annulene
Identifiers
3D model (
JSmol
)
ChemSpider
  • InChI=1S/C20H32/c1-14-7-6-11-20(5)12-10-17-15(2)8-9-16(13-18(14)20)19(17,3)4/h7,16,18H,6,8-13H2,1-5H3/t16-,18+,20-/m0/s1
    Key: FRJSECSOXKQMOD-HQRMLTQVSA-N
  • InChI=1/C20H32/c1-14-7-6-11-20(5)12-10-17-15(2)8-9-16(13-18(14)20)19(17,3)4/h7,16,18H,6,8-13H2,1-5H3/t16-,18+,20-/m0/s1
    Key: FRJSECSOXKQMOD-HQRMLTQVBK
  • C\1(=C2/CC[C@]3(C)CC/C=C(/C)[C@H]3C[C@H](CC/1)C2(C)C)C
Properties
C20H32
Molar mass 272.476 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Taxadiene (taxa-4,11-diene) is a

taxol.[1] Six hydroxylation reactions, and a few others, are needed to convert taxadiene to baccatin III
.

Enzymatically, taxadiene is produced from geranylgeranyl pyrophosphate by taxadiene synthase. A biochemical gram-scale production of taxadiene has been reported in 2010 using genetically engineered Escherichia coli.[2]

References

  1. PMID 8608134
    .
  2. PMID 20929806
    .


Stub icon

This pharmacology-related article is a stub. You can help Wikipedia by expanding it.

Stub icon

This article about an organic compound is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Taxadiene&oldid=1153688387"