Baccatin III

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Baccatin III
Names
IUPAC name
(2β,5α,7α,10α,13β)-4,10-Diacetoxy-1,7,13-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
Identifiers
3D model (
JSmol
)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard
 100.164.451 Edit this at Wikidata
UNII
  • CC1=C2[C@@H](C(=O)[C@@]3([C@@H](C[C@H]4[C@]([C@H]3[C@H]([C@@](C2(C)C)(C[C@H]1O)O)OC(=O)c5ccccc5)(CO4)OC(=O)C)O)C)OC(=O)C
Properties
C31H38O11
Molar mass 586.62677 Da
Melting point 229 to 234 °C (444 to 453 °F; 502 to 507 K)
Acidity (pKa) 12.76
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Baccatin III is an isolate from the yew tree (Genera Taxus). Baccatin III is a precursor to the anti-cancer drug paclitaxel (Taxol).

In 2014, researchers reported introduction and expression of the endophytic fungal gene responsible for synthesizing baccatin III (

Flammulina velutipes.[1] Researchers achieved the same accomplishment with Escherichia coli in 2000.[2]

See also

References

  1. PMID 24403190
    .
  2. PMID 10639122
    .


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