Thiolutin

Thiolutin
Clinical data
Other names	N-(8-methyl-7-oxo-3,4-dithia-8-azabicyclo[3.3.0]octa-1,5-dien-6-yl)acetamide, farcinicin, propiopyvothine, acetopyrrothine
ATC code	none;
Identifiers
	IUPAC name N-(4-methyl-5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl)acetamide;
JSmol)	Interactive image;
	SMILES O=C(NC/2=C/1\SS\C=C\1N(C\2=O)C)C;
	InChI InChI=1S/C8H8N2O2S2/c1-4(11)9-6-7-5(3-13-14-7)10(2)8(6)12/h3H,1-2H3,(H,9,11) ; Key:MHMRAFONCSQAIA-UHFFFAOYSA-N ;
	(what is this?) (verify)

Thiolutin is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases.

mRNA stability. Studies have shown that thiolutin inhibits adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin

and thus suppresses tumor cell-induced angiogenesis in vivo.

Thiolutin is formed in submerged fermentation by several strains of Streptomycetes luteosporeus. Some sources erroneously specify "aureothricin" as a synonym of thiolutin. Aureothricin is an antibiotic very similar to thiolutin, and is created as a by-product during the thiolutin fermentation.^[2]

References

S2CID 9211151
.

^ Fermentek product page

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[1] S2CID 9211151
.

[2] Fermentek product page

[2]