Thymoma-associated multiorgan autoimmunity

Thymoma-associated multiorgan autoimmunity (TAMA)

Thymoma-associated multiorgan autoimmunity (TAMA) is a severe often fatal disease that presents in some patients with thymoma.^[1] It has also been referred to in the medical literature as "thymoma-associated graft-versus-host-like disease".

Presentation

Patients with TAMA present with variable combinations of a morbilliform skin eruption, chronic diarrhea, and abnormal liver enzymes. The histopathology of the skin, liver, or bowel mucosa resembles GVHD.^[2]

Pathophysiology

Thymoma is a common neoplasm arising from the thymus, the primary lymphoid organ where T cells become educated to distinguish "self" from "non self". In the setting of thymoma, abnormal thymic education occurs as a result of subtle differences in antigen processing. In TAMA these differences result in autoreactive T cells escaping from the thymus. This results in a condition similar to graft-versus-host disease.^[1]

Diagnosis

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Treatment

Patients often have a refractory disease course but some patients may respond to phototherapy.^[3]

History

This disease name was coined by Emanual Maverakis and described in detail in 2007 but case reports of graft-versus-host-like disease in the setting of thymoma date back to at least the mid 1990s.^[1][4]

References