Tooth regeneration
Tooth regeneration is a
autologous stem cells.[1]
As a source of the new bioengineered teeth,
somatic stem cells are collected and reprogrammed to induced pluripotent stem cells which can be placed in the dental lamina directly or placed in a reabsorbable biopolymer[2] in the shape of the new tooth.[3]
History
Young et al first demonstrated in 2002 that teeth could be regenerated from cells.[4]
Challenges
The majority of stem cell studies have stopped at the stage of animal studies and have not proceeded to clinical trials due to numerous safety and
tumourigenesis, and metastasis has not yet been resolved.[5]
See also
- Epithelial cell rests of Malassez
- Polyphyodont
- Regenerative endodontics
- Socket preservation
- Tooth development
References
- PMID 24550845.
- ISBN 978-1-59259-428-3.
- ^ Hill, David J. (10 May 2012). "Toothless No More - Researchers Using Stem Cells to Grow New Teeth". Singularity Hub.
- PMID 12351668.
- PMID 37541918.
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