Tyler Jacks
Tyler Jacks | |
---|---|
Alma mater | David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology |
Academic advisors | Robert Weinberg |
Tyler Jacks is a David H. Koch Professor of Biology at the
Early life
Tyler Jacks graduated magna cum laude with Highest Honors in biology from
Career
He was named an Assistant Professor at MIT in 1992 and Associate Professor with
He served on the Board of Scientific Advisors of the National Cancer Institute and is a past president of the American Association for Cancer Research.[8] He also sits on the board of directors at Thermo Fisher Scientific, Inc.[9] and Aveo Pharmaceuticals Inc.[10] He is a member of the Scientific Advisory Board at T2Biosystems, Inc. and at Epizyme, Inc.[11] He was a founding co-editor of the Annual Review of Cancer Biology in 2017,[12] serving until 2021.[13]
Research
He has pioneered the use of gene-targeting technology in mice to study cancer-associated genes and to construct mouse models of many human cancer types.
Awards and recognitions
In 1997, he received the Rhoads Award from the American Association for Cancer Research. In 1998, he won the Amgen Award from the American Society for Biochemistry and Molecular Biology. He has also been named a Ludwig Research Scholar in Cancer Biology from Johns Hopkins University. In 2002, he won the Chestnut Hill Award for Excellence in Medical Research, and in 2005 he won the Paul Marks Prize for Cancer Research. He was elected to the National Academy of Sciences in 2009.[16] In 2014, he was presented the Hope Funds for Cancer Research Award of Excellence for Basic Research.
References
- ^ "Boston.com: Local breaking news, sports, weather, and things to do".
- ^ "Thermo Fisher Scientific Inc. - Investors - Governance - Board of Directors - Person Details".
- ^ "Tyler Jacks".
- ^ "Board of Overseers".
- ^ "Tyler Jacks, Director, Aveo Pharmaceuticals Inc".
- ^ "Tyler Jacks".
- ^ "20 faculty members promoted to full professor". 10 May 2000.
- ^ American Association for Cancer Research Archived 2011-09-30 at the Wayback Machine
- ^ Forbes: Tyler Jacks
- ^ Spoke: Tyler Jacks
- ^ "Stocks". Archived from the original on September 30, 2012.
- .
- ^ "Annual Review of Cancer Biology Editorial Committee". Annual Reviews. 2022. Retrieved 18 July 2022.
- ^ Spoke: Tyler Jacks
- ^ "Tyler Jacks".
- ^ MIT: NAS Members
Publications
- Kumar MS, Lu j, Mercer KL, Golub, TR and Jacks T. 2007. Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nature Genetics, 39(5):673-677
- Shaw AT, Meissner A, Dowdle JA, Crowley D, Magendantz M, Ouyang C, Parisi T, Rajagopal J, Blank LJ, Bronson RT, Stone JR, Tuveson DA, Jaenisch, R, and Jacks, T. 2007. Sprouty-2 Regulates Oncogenic K-ras in Lung Development and Tumorigenesis. Genes & Development, 21(6):694-707.
- McLaughlin ME, Kruger GM, Slocum KL, Crowley D, Michaud NA, Huang J, Magendantz M, and Jacks T. 2007. The Nf2 tumor suppressor regulates cell-cell adhesion during tissue fusion. PNAS,104(9):3261-3266.
- Ventura, A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R and Jacks T. 2007. Restoration of p53 function leads to tumor regression in vivo. Nature, 445, 661-665
- Macpherson D, Conkrite K, Tam M, Mukai S, Mu D, and Jacks T. 2007. Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification. EMBO J, 26, 784-794
- Carla F. Kim, Erica L Jackson, Amber E Woolfenden, Sharon Lawrence, Imran Babar, Sinae Vogel, Denise Crowley, Roderick T Bronson, Tyler Jacks 2005. Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell, 121(6):823-835.
- Alejandro Sweet-Cordero, Sayan Mukherjee, Aravind Subramanian, Han You, Jeff Roix, Christine Ladd, Todd R. Golub, Tyler Jacks. 2005. An oncogenic Kras expression signature identified by cross-species gene expression analysis. Nature Genetics, 37 (1), 48-55
- Daniela M. Dinulescu, Tan A. Ince, Bradley J. Quade, Sarah A. Shafer, Denise Crowley, Tyler Jacks. 2005. Role of K-ras and Pten in the Development of Mouse Models of Endometriosis and Endometrioid Ovarian Cancer. Nature Medicine, 11 (1), 63–70.
- Kenneth P. Olive, David A. Tuveson, Zachary C. Ruhe, Bob Yin, Nicholas A. Willis, Roderick T. Bronson, Denise Crowley, Tyler Jacks. 2004. Mutant p53 Gain-of-Function in Two Mouse Models of Li-Fraumeni Syndrome. Cell, 119 (6), 847–860.
- Ventura A, Meissner A, Dillon CP, McManus M, Sharp PA, Van Parijs L, Jaenisch R, Jacks T. 2004. Cre-lox-regulated conditional RNA interference from transgenes. PNAS (101):10380-10385.