User:Leofef/sandbox
Arylsulfatase B was recently studied as a potential biomarker of prostate cancer [1]
Halley's comet caused a famine [2]
Possible role in development of diabetes
Recent study showed that mice that consumed carrageenan in their drinking water had
Role in cystic fibrosis
Expression and activity of ARSB were found to be related to the function of cystic fibrosis transmembrane conductance regulator (CFTR), the membrane channel deficient in cystic fibrosis. Measurements in cystic fibrosis cell line IB3 and its derivative cell line C38, which has a functional CFTR, showed increased ARSB activity and expression in the C38 line. [4] CFTR potentiator VRT-532 increased ARSB expression and activity in cystic fibrosis cells to the level in the normal bronchial epithelial cells. [5]
Extra-lysosomal localization
Although primarily a lysosomal enzyme, ARSB was also found to localize at the cell membrane of
Role in malignancy
ARSB has been studied in a variety of cancers. Cultured normal mammary epithelial and
Role in metabolism
Reduced sulfate availability due to impaired activity of ARSB has been linked to increased
References
- ^ L Feferman, S Bhattacharyya, R Deaton, P Gann, G Guzman, A Kajdacsy-Balla and JK Tobacman. Arylsulfatase B (N-acetylgalactosamine-4-sulfatase): potential role as a biomarker in prostate cancer. Prostate Cancer and Prostatic Disease advance online publication, 9 July 2013; doi:10.1038/pcan.2013.18
- ^ Mike Wall. Why Halley's Comet May Be Linked to Famine 1,500 Years Ago. Life Science. December 19, 2013
- ^ S Bhattacharyya, I O-Sullivan, S Katyal, T Unterman,and JK Tobacman. Exposure to the common food additive carrageenan leads to glucose intolerance, insulin resistance and inhibition of insulin signalling in HepG2 cells and C57BL/6J mice. Diabetologia (2012) 55:194–203
- ^ Sumit Bhattacharyya, Dwight Look, Joanne K. Tobacman. Increased arylsulfatase B activity in cystic fibrosis cells following correction of CFTR. Clinica Chimica Acta, Volume 380, Issues 1–2, 1 May 2007, Pages 122–12
- ^ Sumit Bhattacharyya,Leo Feferman, Joanne K. Tobacman. Effect of CFTR modifiers on arylsulfatase B activity in cystic fibrosis and normal human bronchial epithelial cells. Pulmonary Pharmacology & Therapeutics 36 (2016)22-30
- ^ Keiko Mitsunaga-Nakatsubo, Shinichiro Kusunoki, Hayato Kawakami, Koji Akasaka, Yoshihiro Akimoto. Cell-surface arylsulfatase A and B on sinusoidal endothelial cells, hepatocytes, and Kupffer cells in mammalian livers. Med Mol Morphol (2009) 42:63–69 DOI 10.1007/s00795-009-0447-x
- ^ a b Sanjiv V. Prabhu, Sumit Bhattacharyya, Grace Guzman-Hartman, Virgilia Macias, André Kajdacsy-Balla, Joanne K. Tobacman. Extra-Lysosomal Localization of Arylsulfatase B in Human Colonic Epithelium. J Histochem Cytochem March 2011 vol. 59 no. 3 328-335 doi: 10.1369/0022155410395511
- ^ a b L Feferman, S Bhattacharyya, R Deaton, P Gann, G Guzman, A Kajdacsy-Balla, and JK Tobacman. Arylsulfatase B (N-acetylgalactosamine-4-sulfatase): potential role as a biomarker in prostate cancer. Prostate Cancer and Prostatic Disease (2013), 1–8
- ^ Sumit Bhattacharyyaa, Joanne K. Tobacman. Steroid sulfatase, arylsulfatases A and B, galactose-6-sulfatase, and iduronate sulfatase in mammary cells and effects of sulfated and non-sulfated estrogens on sulfatase activity. The Journal of Steroid Biochemistry and Molecular Biology. Volume 103, Issue 1, January 2007, Pages 20–34
- ^ S Bhattacharyya, L Feferman and JK Tobacman. Arylsulfatase B regulates versican expression by galectin-3 and AP-1 mediated transcriptional effects. Oncogene (2013), 1–10
- ^ Sumit Bhattacharyya, Leo Feferman and Joanne K. Tobacman. Increased Expression of Colonic Wnt9a through Sp-1 mediated Transcriptional Effects Involving Arylsulfatase B, Chondroitin-4-Sulfate, and Galectin-3. J. Biol. Chem. published online April 28, 2014
- ^ Sumit Bhattacharyya, Leo Feferman, Joanne K. Tobacman. Inhibition of Phosphatase Activity Follows Decline in Sulfatase Activity and Leads to Transcriptional Effects through Sustained Phosphorylation of Transcription Factor MITF. PLOS ONE April 14, 2016
- ^ Sumit Bhattacharyya, Leo Feferman, Kaoru Terai, Arkadiusz Z. Dudek, Joanne K. Tobacman. Decline in arylsulfatase B leads to increased invasiveness of melanoma cells. Oncotarget. December 1, 2016.
- ^ Sumit Bhattacharyya, Leo Feferman, Joanne K. Tobacman. Restriction of Aerobic Metabolism by Acquired or Innate Arylsulfatase B Deficiency: A New Approach to the Warburg Effect. Scientific Reports. September 8, 2016