User:Mimosa taco/Clinical chemistry

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Clinical chemistry (also known as chemical pathology, clinical biochemistry or medical biochemistry) is the area of chemistry that is generally concerned with analysis of bodily fluids for diagnostic and therapeutic purposes. It is an applied form of biochemistry (not to be confused with medicinal chemistry, which involves basic researchfor drug development).

The discipline originated in the late 19th century with the use of simple

with extensive diagnostic capabilities.

Most current laboratories are now highly automated to accommodate the high workload typical of a hospital laboratory. Tests performed are closely monitored and quality controlled.

All biochemical tests come under chemical pathology. These are performed on any kind of

" principle. Plasma is in essence the same as serum, but is obtained by centrifuging the blood without clotting. Plasma is obtained by centrifugation beforeclotting occurs. The type of test required dictates what type of sample is used.

A large medical laboratory will accept samples for up to about 700 different kinds of tests. Even the largest of laboratories rarely do all these tests themselves, and some must be referred to other labs.

This large array of tests can be categorised into sub-specialities of:

• General or routine chemistry – commonly ordered blood chemistries (e.g., liver and kidney function tests).
• Special chemistry - elaborate techniques such as
  electrophoresis
  , and manual testing methods.
• Clinical endocrinology – the study of hormones
  , and diagnosis of endocrine disorders.
• drugs of abuse
  and other chemicals.
• Therapeutic Drug Monitoring – measurement of therapeutic medication levels to optimize dosage.
• Urinalysis – chemical analysis of urine for a wide array of diseases, along with other fluids such as CSF and effusions
• Fecal analysis – mostly for detection of gastrointestinal disorders.

Revised Article ==== Lead

Clinical chemistry (also known as chemical pathology,.....) is a division in medical laboratory sciences focusing on qualitative tests of important compounds, referred to as analytes or markers, in bodily fluids and tissues using analytical techniques and specialized instruments.^[1]  This interdisciplinary field includes knowledge from medicine, biology, chemistry, engineering, informatics, and biochemistry.

Clinical chemists use automated clinical chemistry analyzer in many clinical laboratories, which perform experimental techniques ranging from pipetting specimens and specimen labelling to advanced measurement techniques such as spectrometry, chromatography, photometry, potentiometry, etc . ^[2]These instruments provide different results that help identify uncommon analytes, changes in light and electronic voltage properties of naturally-occurring analytes such as enzymes, ions, electrolytes, and their concentrations, all of which are important for diagnosing diseases. Most current laboratories are now highly automated to accommodate the high workload typical of a hospital laboratory. Tests performed are closely monitored and quality controlled.

Blood and urine are the most common test specimens clinical chemists or medical laboratory scientists collect for clinical routine tests, with a main focus on serum and plasma in blood.^[3] They serve as the interface between the laboratory side and the clinical practice, providing suggestions to physicians on which tests to order and interpret any irregularities in test results that reflect on the patient's health status and organ system functionality.^[4] This allows healthcare providers to make more accurate evaluation of a patient's health and to diagnose disease, predicting the progression of a disease (prognosis), screening, and monitoring the treatment's efficiency in a timely manner.

Chemistry Panel Tests

A physician may order multiple laboratory tests on one specimen, referred to as a panel, when a single test cannot provide sufficient information to make a swift and accurate diagnosis and treatment plan. A test panel performs multiple tests on one sample to assess changes in multiple analytes that may be indicative of specific medical concerns or the health status of an organ system.^[5] Thus, panel tests provide a more extensive evaluation of a patient's health, have higher predictive values for confirming or disproving a disease, and are quick and cost-effective.

Metabolic Panel

A Metabolic Panel (MP) is a routine group of blood tests commonly used for health screenings, disease detection, and monitoring vital signs of hospitalized patients with specific medical conditions. The panel analyzes common analytes in the blood to assess the functions of the kidneys and liver, as well as electrolyte and acid-base balances. There are two types of MPs - Basic MP (BMP) or Comprehensive MP (CMP)^[6].

Basic Metabolic Panel (BMP)

BMP is a panel of tests that measures eight analytes in the blood's fluid portion (plasma). The results of the BMP provide valuable information about a patient's kidney function, blood sugar level, electrolyte levels, and the acid-base balance. Abnormal changes in one or more of these analytes can be a sign of serious health issues:

• Sodium, Potassium, Chloride, and Carbon Dioxide: they are electrolytes that have electrical charges that manage the body’s water level, acid-base balance in the blood, and kidney function^[7].
• Calcium: This charged electrolyte is essential for the proper functions of nerve, muscle, blood clotting, and bone health. Changes in the calcium level can indicate bone disease, muscle cramps/ spasms, thyroid disease, and other conditions.^[8]
• Glucose: This measures the blood sugar levels, which is a crucial energy for your body and brain. High glucose levels can be a sign of diabetes or insulin resistance. ^[7]
• Urea and Creatinine: These are waste products that the kidney filters out from blood. Urea measurements are helpful in detecting and treating kidney failure and related metabolic disorders, whereas creatinine measurements give information on kidney’s health, track of renal dialysis treatment, and monitor hospitalized patients that are on diuretics.^[7]