User:Mr. Ibrahem/Entacapone

Source: Wikipedia, the free encyclopedia.
Mr. Ibrahem/Entacapone
Skeletal formula
Space-filling model of entacapone
Clinical data
Pronunciation/ˌɛntəkəˈpoʊn/ or /ɛnˈtækəpoʊn/
Trade namesComtan, Comtess, others
AHFS/Drugs.comMonograph
MedlinePlusa601236
License data
Pregnancy
category
  • AU: B3
Routes of
administration		By mouth
Drug classCOMT inhibitors[1]
Legal status
Legal status
Pharmacokinetic data
Bioavailability35%
Protein binding98% (binds to serum albumin)
MetabolismLiver
Elimination half-life0.4–0.7 hours
ExcretionFeces (90%), urine (10%)
Identifiers
  • (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide
Chemical and physical data
JSmol)
  • [O-][N+](=O)c1cc(\C=C(/C#N)C(=O)N(CC)CC)cc(O)c1O
  • InChI=1S/C14H15N3O5/c1-3-16(4-2)14(20)10(8-15)5-9-6-11(17(21)22)13(19)12(18)7-9/h5-7,18-19H,3-4H2,1-2H3/b10-5+ checkY
  • Key:JRURYQJSLYLRLN-BJMVGYQFSA-N checkY
  (verify)

Entacapone, sold under the brand name Comtan among others, is a medication used to treat

levodopa/carbidopa before the next dose is due.[1] It is taken by mouth.[3]

Common side effects include uncontrollable movements, nausea, and

hallucinations.[1] It works by blocking the enzyme that breaks down levodopa, catechol-O-methyltransferase (COMT).[2]

Entacapone was approved for medical use in Europe in 1998 and the United States in 1999.

generic medication.[3] In the United Kingdom 100 tablets of 200 mg costs the NHS about £16 as of 2021.[3] This amount in the United States costs about 40 USD.[4]

References

  1. ^ a b c d e f "Entacapone Monograph for Professionals". Drugs.com. Archived from the original on 8 May 2021. Retrieved 15 December 2021.
  2. ^ a b c d "Comtess". Archived from the original on 12 November 2020. Retrieved 15 December 2021.
  3. ^
    ISBN 978-0857114105
    .
  4. ^ "Entacapone Prices and Entacapone Coupons - GoodRx". GoodRx. Retrieved 15 December 2021.
Retrieved from "https://en.wikipedia.org/w/index.php?title=User:Mr._Ibrahem/Entacapone&oldid=1195491504"