User talk:Friedfish/Archive 2006Q4

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Hi. Thanks for all the contributions you have made to Seliciclib. It's an interesting drug, we need to get the story out there. I wanted to talk about the grammar and content of the article's introductory paragraph. You have changed it to read:

R-roscovitine (Seliciclib or CYC202) is a trial drug in the family of pharmacological cyclin-dependent kinase (CDK) inhibitors that preferentially inhibit multiple enzyme targets including CDK2, CDK7 and CDK9, which alter the growth phase or state within the cell cycle of treated cells. Seliciclib is being developed by Cyclacel.

I have some issues with this phrasing, as follows:

• The first sentence is a run-on. (is a drug, that inhibit, which alter...)
• It reads as though all PCIs preferentially inhibit just CDKs2,7 and 9. But this is true of R-Roscovitine, not PCIs in general. In particular, the conjugation of 'inhibit' vs. 'inhibits' makes this seem to apply to PCIs the plural not Roscovitine the singular. This is not correct, but probably an artefact of the sentence's overly-complicated construction.
• It is unclear what the antecedent of 'which' in 'which alter' is meant to be. The reader could take it to mean either CDKs alter the growth phase (arguably true) or PCIs do (possibly not always true, but actually usually true and true in the case of Roscovitine).
• I would rather see the link to Cyclacel read Cyclacel Pharmaceuticals, Inc. because that is the proper name of the owner of this compound's IP stuffs.

I like these things about it:

• Calls it a trial drug in the PCI class.
• Brings CDK2,7,9 selectivity of Roscovitine into the 1st paragraph.

My main suggestion would be that we 'factor' this paragraph into some declarative sentences with few subclauses. In my opinion, this is the path to more incisive writing.

Perhaps:

R-roscovitine (Seliciclib or CYC202) is a trial drug in the family of Pharmacological Cyclin-Dependent Kinase (CDK) Inhibitors (PCIs). CDKs moderate the cell cycle and Pharmacological CDK Inhibitors inhibit one or more CDKs. Seliciclib selectively inhibits CDK2, CDK7 and CDK9. Seliciclib alters the growth phase of treated cells (cells accumulate in G(2)?). Seliciclib is being developed by Cyclacel Pharmaceuticals, Inc.

Not exactly that. It is a hard topic to explain, we both know. I just hope we can come up with something more accessible to the reader who is wandering into the topic for the first time.

Anyway, I'm looking forward to contributing more with you. Kind regards. ManVhv 02:26, 5 October 2006 (UTC)

lavori in corso - just want to check a couple of things first; not sure of role of phosphatases - good point about my run-on sentence! Kind regards. → friedfish 19:45, 7 October 2006 (UTC)

So, are you going to fix that, or just be clever in your reply? ManVhv 00:32, 14 November 2006 (UTC)

Hi. Good point – I certainly have not forgotten. There have been a few concerns raised elsewhere about the page. The page currently reads like a list, the references - although well researched - tend to distract from the article's content and the potential pharmaceutical applications need to be curtailed. → friedfish 08:16, 14 November 2006 (UTC)

With a "pie and a pint" ( ahhh, I love Scotland ) in hand, you did a good job on my typo's in

David Dempster 17:15, 7 October 2006 (UTC)

I can live with the way ECM is defined now in the article. My above comment was from reading what showed on the "history" page and the highlighted changed area. For some reason, more data is printed there than in the actual article itself. One more mystery of the Wikipedia system!

David Dempster 17:33, 7 October 2006 (UTC)

You're welcome, David!; hangar and hanger is a tricky one. The article is really excellent. As for ECM, or Electronic Countermeasures, link was just to make it link to the Wikipage. → friedfish 19:45, 7 October 2006 (UTC)

About the Cookie Crew 1987 track "Rok Da House"
– There is no Wiki-article on Scoop (band); perhaps this could be added. Members of band would seem to be Daniël Moerenhout and Jan Vervloet.
– There are numerous songs/tracks with the title "Rock da House" or the variant which you find hard to distinguish, "Rock the house"; after ending up with a list over a fifty, I decided to stop compiling a list. Even Wikipedia itself boasts a couple of dozen, notably Rock the House by Gorillaz.
– And the 13 year time gap is relevant as the Beatmasters/Cookie Crew version was neither competing with nor confused with the Scoop track during 1987 as it gained popularity in the clubs - a claim that could be made namesake track by

Scoop the band is mentioned on the diambiguation page of scoop, but I was not able to find enough material for an article. In the limited context you set, you are correct about the time gap, but it IS irrelevant for today's researcher. A researcher looking for the Cookie Crew in European sources who doesn't know the spelling should be "ROK" will turn up the Scoop number instead, particularly if you hunt for the mp3 on Limewire. However, the statement that there are a vast number of songs titled "Rock Da House" is correct. With regard to genre, all the sources referring to ROK DA HOUSE that I found categorise it as "House Music" and a few claim it as the first house hit. ...The only point I feel strongly on is that the comparison to Scoop should stay because of my own personal experience of confusing the two. Headshaker 05:14, 10 October 2006 (UTC)

So a couple of minor points:
– I thought you put the Scoop (band) on the disambiguation page on 17 March 2006 Change edit. Another interesting fact that I managed to find out about "Scoop" - their 1999/2000 single "Drop it" was the first Belgian number one in Holland since Technotronic.
– Thank you for correcting my typo - I was trying to correct the Scoop song not the Cookie Crew song. From discogs, the release title of Scoop record is "Rock the house" and sleeve also has this title Photo of cover.
– Not sure of your point of "researchers" making a mistake between Beatmasters with Cookie Crew track and Scoop track. You should encourage young people to go down to a vinyl record store buy both records and start a club somewhere. As for hunting on limewire, well...
– The only other song that has reached the Top 100 of UK Singles Chart since 1952 with the title "Rok da house" was Vinylgroover And The Red Hed in January 2001 (#72) - Source And Nicole and Gorillaz had tracks called "Rock the house" in December 1992 (#63) and November 2001 (#72), respectively.
– As the track was essentially by Beatmasters, the "genre" is much more likely to be "house" rather than "hip house" that the article states. → friedfish 09:46, 10 October 2006 (UTC)

We seem to have reached a good compromise and useful exchange of knowledge. The reference to "Hip House" was not my edit by the way. I am now happy with the article as it stands but will be equally happy for others to expand it. Headshaker 17:57, 10 October 2006 (UTC)

Hello. I like and agree with many of the changes that you have made on the GLJ page. The one error is calling genelovesjezebel.co.uk an official site. Michael Aston was the victorious party in a civil suit instituted by Jay Aston over trademark rights to the name "Gene Loves Jezebel" and Michael Aston was also the winner of an ICANN arbitration with Jay Aston over the rights to the domain name "genelovesjezebel.com". Accordingly, it has been conclusively and finally established in two different forums that Michael Aston is the sole and exclusive owner of the trademark and domain name "Gene Loves Jezebel". The .co.uk site is at best a fan site, not the official one. Ghost 16:11, 11 October 2006 (UTC)

Hello. As the article seemed to borrow from a BBC Wales article it was only my "duty" to correct the chart positions. Also, the NPOV stuff from the "KROQ, Top 106.7 Countdown of 198X" made little encyclopedic sense. But this official/unofficial websites stuff... — both claim to be official for the various segments of the band - it's painful (pitiful) - I guess "domain names" and ™ is more complicated. John Peter Aston registered the genelovesjezebel.co.uk during 2000, whereas Michael Aston (Aston Management Group) registered genelovesjezebel.com and genelovesjezebel.net during 1998; genelovesjezebel.org during 2000 and "Round Flat Records" gobbled up genelovesjezebel.info last May; does this mean another court battle? → friedfish 16:58, 11 October 2006 (UTC)

Ha ha, I know it does get kind of crazy. Ghost 16:31, 12 October 2006 (UTC)]

Hey Friedfish. There has been some vandalism over on the GLJ page. Is there any way to stop that? (Ghost 17:47, 14 December 2006 (UTC))

Hello. There should be a slow down for the moment, we'll see over the coming hours... → friedfish 18:49, 14 December 2006 (UTC)

Brian Souter's involvement with "Keep the clause" is well reported, but could you cite Ann Gloag's involvement other than hearsay e.g. other than ScotsGay Magazine January 2000 or Spectrezine. Brian Souter is mentioned in the wikiarticle, I have cleared this up. As she is a living person, her religious beliefs are not relevant unless in reference to her upbringing or she has a prominent role within that organisation. Also, "At the turn of the Millenium" besides spelling error, implies that these events were in 2001 when the poll was conducted in 2000. → friedfish 17:09, 19 October 2006 (UTC)

This is a biographical article. Of course her religious stance is important, what's wrong with that? Just about every other major biographical article has some information on someone's upbringing, family religion, current belief etc, this is hardly unusual. "Turn of the Millenium" refers to around that time - 2000 qualifies even with the 2001 definition. Apart from some pedants, few people saw 2001 as the Millenium. They're usually the type of people that going on about how monkeys aren't apes, and dolphins aren't fish - all well and good, and true, but a good way of clearing a room... --MacRusgail 16:16, 23 October 2006 (UTC)

Hi, thank you for you input → friedfish 16:39, 23 October 2006 (UTC)

Are you anti-gay or something? Personally I couldn't give a toss (no pun intended, and "fur cough", isn't a pun in my accent. We pronounce the "r"). What's with the religious thing anyway? You still haven't answered that. --MacRusgail 16:38, 25 October 2006 (UTC)

SUPP --- Not-sure-what this user is aiming for but certainly not encyclopedic information. Oh well, seems to be