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Autophagy is an important cellular process that helps in maintaining homeostasis. It goes through destroying and recycling the of cytoplasmic organelles and macromolecules. During the initiation of autophagy, ATG7 acts like an E-1 enzyme for ubiquitin-like proteins (UBL) such as ATG12 and ATG8. ATG7 helps these UBL proteins in targetting their molecule by binding to them and activating their transfer to an E-2 enzyme.Atg7's role in both of these autophagy-specific UBL systems makes it an essential regulator of autophagosome assembly.[1]

Snowy0597 (talk) 03:12, 27 March 2018 (UTC)[reply]

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Reviewing the article

The ATG7 article has a summary of what that gene is, functions, etc. but it doesn't describe the full role of that gene on human or other species. There should be more summary of how it works in detail including its effects on other genes like ATG12, ATG5, etc.

It should also include that the oxidation of ATG7 along with ATG3 inhibits autophagy. How would antibody of ATG 7 impact on a mouse or on a human being? Does it have anything to do with cancer?

Snowy0597 (talk) 20:54, 7 April 2018 (UTC)[reply]

If possible put a picture to help visualize the concept. Add some examples with proper explanation to help the readers understand autophagy more in-depth. Fix typos and capitalize words where necessary. remove the word "on" after impact in the first question. In addition, explain the imporance of autophagy in the human body and what would happen if this essential process is not carried out properly. 137.142.161.173 (talk) 18:42, 14 May 2018 (UTC)[reply]

Wiki Education Foundation-supported course assignment

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Snowy0597.

Above undated message substituted from

talk) 20:31, 19 January 2022 (UTC)[reply
]

Wiki Education Foundation-supported course assignment

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Cashmeresilk. Peer reviewers: Cashmeresilk.

Above undated message substituted from

talk) 20:31, 19 January 2022 (UTC)[reply
]

References

  1. ^ "ATG7 - an E1 enzyme for the ubiquitin-like autophagy proteins".