Utopioid (drug class)
Utopioids (U-type opioids) are a class of synthetic
mu opioid receptor selective compound from this class, U-47700, re-emerged as a designer drug and became widely sold around the world for several years before being banned in various jurisdictions from 2016 onwards. Following the prohibition of U-47700, a number of related compounds have continued to appear on illicit drug markets. They are often marketed online or included as components in mixtures sold under the guise of "street heroin." U-47700 itself is the most potent mu opioid agonist from this class, around 7-10x the potency of morphine. Some other compounds such as 3,4-MDO-U-47700 and N-Ethyl-U-47700 retain similar mu selectivity but with lower potency similar to that of morphine, or have a mixture of mu and kappa mediated effects, such as U-48800. Most utopioid derivatives are however selective kappa agonists, which may have limited abuse potential as dissociative hallucinogens, but do not alleviate withdrawal distress in opioid dependent individuals or maintain addiction in a typical sense. Nevertheless, this has not stopped them from being sold as designer drugs, and a number of these compounds are now banned in many jurisdictions alongside U-47700 itself.[2][3][4][5][6][7][8][9]
Table of Utopioids
Chemical structure | Drug name | PubChem | CAS number |
---|---|---|---|
U-47109 | 44269286 | 67579-13-9 | |
U-47700 | 13544016 | 82657-23-6 | |
U-47931E (Bromadoline) | 6328449 | 2418521-61-4 | |
U-48520 | 13544026 | 67579-11-7 | |
U-48800 | 137700072 | 2370977-17-4 | |
U-49900 | 129392412 | 67579-76-4 | |
U-50211 [10] | 13544017 | 98587-47-4 | |
U-50488 | 3036289 | 67198-13-4 | |
U-51574 | 44269303 | ||
U-62066 (Spiradoline) | 55652 | 87151-85-7 | |
U-69593 | 105104 | 96744-75-1 | |
U-77891 | 117071705 | 119878-31-8 | |
N-Desmethyl-U-47700 | 129390993 | 67579-73-1 | |
N,N-Didesmethyl-U-47700 | 129406364 | 2616858-81-0 | |
3,4-MDO-U-47700 | 139598237 | 2488874-96-8 | |
3,4-Ethylenedioxy-U-47700 | 137700298 | 2749619-08-5 | |
3,4-Ethylenedioxy-U-51574 | 137700374 | 2748623-91-6 | |
N-Ethyl-U-47700 | 155907846 | ||
N-Propyl-U-47700 | 137700434 | 2749433-76-7 | |
N-Isopropyl-U-47700 | 137700166 | 2748319-16-4 | |
N-Cyclopropyl-U-47700 | 165361451 | ||
N-Methoxy-U-47700 | 155907659 | ||
N-Methyl-U-47931E | 54482637 | 75570-38-6 | |
3,4-Dibromo-U-47700 | |||
3,4-Difluoro-U-47700 | 165362347 | 2417942-54-0 | |
2,4-Difluoro-U-48800 | |||
4-TFM-U-48520 (U-04) | 53720446 | 67579-38-8 | |
α-U10 | 165362154 | 2417942-61-9 | |
β-U10 | 54524276 | 67579-80-0 |
See also
References
- ^ "Utopioids". Cayman Chemical News and Announcements. 12 July 2018.
- S2CID 21404877.
- PMID 30636980.
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- PMID 33238449.
- S2CID 246239574.
- S2CID 246701889.
- ^ "Non-fentanyl opioids and related new psychoactive substances with no known legitimate uses" (PDF). International Narcotics Control Board. 28 January 2022.
- S2CID 260101432.
- PMID 2831361