V. Sasisekharan

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V. Sasisekharan
Born (1933-06-28) 28 June 1933 (age 90)
India
Nationality
Shanti Swarup Bhatnagar Prize
1981 FICCI Award
1983 INSA J. C. Bose Medal
1985 Hari Om Ashram J. C. Bose Award
1987 Watumull Honor Summus Medal
1989 Om Prakash Bhasin Award
Scientific career
Fields
Institutions

Viswanathan Sasisekharan (born 1933) is an Indian biophysicist known for his work on the structure and conformation of

polypeptide and protein conformation, a central principle of the (φ, ψ) plot (later known as the Ramachandran plot).[1][2][3] Additionally, he was the first to introduce alternative models of DNA structure that provided insights beyond the standard double helix model.[4][5][6] For his contributions to the biological sciences, he was awarded the Shanti Swarup Bhatnagar Prize for Science and Technology, one of India’s highest science awards, in 1978.[7]

Education and career

V. Sasisekharan was born on 28 June 1933 in the South Indian state of Tamil Nadu. He earned his Ph.D. from the University of Madras in 1959.[8] From 1959–1963, he was a lecturer at the University of Madras, and from 1963–1964, he was a visiting scientist at the National Institutes of Health (NIDDK).[8] In 1964, he joined the University of Madras as a reader at the Centre of Advanced Study in Physics and served as a professor and administrative head of the Department of Physics from 1968–1970 and 1971–1972.[8] He was a visiting professor at Princeton University at their Frick Chemical Laboratory from 1970–1971.[8]

In 1972, Sasisekharan moved to the Indian Institute of Science (IISc) Bangalore, where he served as the professor and chairman of the Molecular Biophysics Unit; chairman of the Division of Chemical and Biological Sciences; and dean of the Faculty of Science. He was a visiting professor at the University of Chicago, and was an adjunct professor at the School of Pharmacy, University of California, San Francisco.[9]

Research

As a graduate student, Sasisekharan studied the structure of

crystal structures at the time, the (φ, ψ) plot has remained nearly unchanged for 60 years.[3]

Later in his career, part of Sasisekharan’s work focused on the structure of nucleic acids. He and his coworkers demonstrated that the available experimental results were compatible with both right- and left-handed double helical models for DNA. They also showed the enormous degree of conformational flexibility in the basic units of DNA and highlighted the concept of sequence specific conformation and DNA conformational polymorphism. In addition, they proposed a structure of DNA consisting of alternating left- and right-handed helical segments, known as the side-by-side (S-B-S) model, an alternative to the right-handed double helix model.[4][5][6] The S-B-S model offered greater structural flexibility that could facilitate the uncoiling of the double helix without topological rearrangement during replication or other processes.[4][5][6][12]

His son, Ram Sasisekharan, is a bioengineer[13][14] and a co-author of some of his publications.[15]

Awards and honors

The

University Grants Commission of India.[8] He was awarded the Honor Summus Medal of the Watunull Foundation in 1987 and was selected as a Fogarty Scholar-In-Residence at the National Institutes of Health in 1988. He received the Om Prakash Bhasin Award in 1989.[17] Sasisekharan was elected fellow of the Indian Academy of Sciences in 1969[18] and fellow of the Indian National Science Academy in 1980.[8]

See also

References

  1. ^ a b c Sasisekharan, V (1962). Ramanathan, N (ed.). Stereochemical Criteria for Polypeptide and Protein Structures. New York: John Wiley. pp. 39–77. {{cite book}}: |work= ignored (help)
  2. ^
    PMID 13990617
    .
  3. ^
    PMID 21436958
    .
  4. ^ a b c Sasisekharan, V; Pattabiraman, N (1976). "Double stranded polynucleotides: two typical alternative conformations for nucleic acids" (PDF). Current Science. 45: 779–783. Archived from the original (PDF) on 13 December 2019. Retrieved 21 June 2020.
  5. ^
    S2CID 4145327
    .
  6. ^
    PMID 279899
    .
  7. ^ a b "View Bhatnagar Awardees". Shanti Swarup Bhatnagar Prize. 2016. Retrieved 19 September 2016.
  8. ^ a b c d e f "Indian Fellow - Sasisekharan". Indian National Science Academy. 2016. Retrieved 23 September 2016.
  9. ^ University of California, San Francisco. School of Pharmacy (1979). UCSF School of Pharmacy Bulletin. The University. pp. 4–.
  10. ^ Sasisekharan, V (1959). "Structure of collagen and related compounds". PhD Thesis, University of Madras.
  11. PMID 4882249
    , retrieved 21 June 2020
  12. JSTOR 24110017
    .
  13. ^ Jayan, T.V. (10 June 2013). "Sugary route to success". The Telegraph. Archived from the original on 15 June 2013. Retrieved 26 April 2018.
  14. ^ "Ram Sasisekharan, PhD | MIT Department of Biological Engineering". be.mit.edu. Retrieved 21 June 2020.
  15. ISBN 978-0-444-62670-7
    .
  16. ^ "The Jagadis Chandra Bose Medal". INSA. 2016. Archived from the original on 16 September 2016. Retrieved 24 September 2016.
  17. ^ "OPB Awards". Om Prakash Bhasin Foundation. 2014. Archived from the original on 6 November 2020. Retrieved 23 September 2016.
  18. ^ "Fellow Profile". Indian Academy of Sciences. 2016. Retrieved 24 September 2016.
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