W. Wallace Cleland

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William Wallace Cleland
University of Wisconsin

William Wallace Cleland (January 6, 1930 – March 6, 2013

National Academy of Sciences
in 1985.

Life and education

Cleland was born in 1930 in

Baltimore, Maryland. He received his A.B. from Oberlin College in 1950 and his M.S. and Ph.D. from the University of Wisconsin–Madison in 1953 and 1955, respectively.[3] He was an avid stamp collector and was awarded the Lifetime Achievement Award in Philately by the Smithsonian Institution in 2008. Cleland died on March 6, 2013, after falling on ice.[4]

Career

After carrying out postdoctoral research at the University of Chicago he returned to University of Wisconsin–Madison, where he became assistant professor in 1959. In 1962 he was promoted to associate professor and then professor in 1966. He became J. Johnson Professor of Biochemistry in 1978, and Steenbock Professor of Chemical Science in 1982.[2]

Kresge, Simoni and Hill[5] have presented a general appreciation of Cleland's life and career.

Scientific contributions

Papers

Cleland's research focused on the use of enzyme kinetics to deduce enzyme mechanisms, especially those involved in phospho and acyl transfers.[3] He pioneered the kinetic and mechanistic study of enzymes with more than one substrate, and he was probably the first to make a systematic classification of mechanisms and the corresponding kinetic equations.[6][7][8] Building on this work he made kinetic studies of various enzymes, including isotope exchange of creatine kinase.[9]

Cleland was a pioneer in the use of computers to analyze enzyme kinetic data,[10] and his Fortran programs that implement Wilkinson's analysis,[11] which he distributed to anyone who requested them, were very influential.

In the latter part of his career Cleland contributed greatly to studies of the use of kinetic isotope effects as a tool for elucidating mechanisms of enzyme catalysis.[12]

He was the first to use dithiothreitol for the reduction of disulfide bonds in proteins, and the compound is accordingly often called Cleland's reagent.[13]

Book

Enzyme Kinetics and Mechanism (with P. F. Cook, 2007)[14]

Awards and recognition

References

  1. ^ "In Memoriam". National Academy of Sciences. Retrieved 8 March 2013.
  2. ^ a b Academic home page
  3. ^ a b c d e f g J. Biol. Chem. biographical article
  4. ^ "Biochemistry Mourns the Loss of "Mo" Cleland". News 2013. Department of Biochemistry, UW-Madison. 6 March 2013. Retrieved 9 March 2013.
  5. doi:10.1016/S0021-9258(19)35036-7
    .
  6. doi:10.1016/0926-6569(63)90227-X
    .
  7. doi:10.1016/0926-6569(63)90211-6
    .
  8. doi:10.1016/0926-6569(63)90226-8
    .
  9. doi:10.1016/S0021-9258(18)96891-2
    .
  10. S2CID 4261285
    .
  11. PMID 13785321
    .
  12. doi:10.1002/jlcr.1390
    .
  13. PMID 14192894
    .
  14. ISBN 978-0-8153-4140-6
    .
  15. ^ "Cleland, W. Wallace "Mo"". Madison.com. March 10, 2013. Retrieved 12 March 2013.
  16. ^ "36th Symposium: Enzyme Structure and Function". University of Wisconsin–Madison. Retrieved 29 August 2023.

External links

Retrieved from "https://en.wikipedia.org/w/index.php?title=W._Wallace_Cleland&oldid=1172830268"