XRN1 (gene)
| XRN1 | |||
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| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process |
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| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) |
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| Location (UCSC) | Chr 3: 142.31 – 142.45 Mb | Chr 9: 95.84 – 95.94 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
5′-3′ exoribonuclease 1 (Xrn1) is a protein that in humans is encoded by the XRN1 gene. Xrn1 hydrolyses RNA in the 5′ to 3′ direction.[5][6]
Function
This gene encodes a member of the 5′-3′
bone formation. Alternative splicing
results in multiple transcript variants.
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000114127 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032410 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 18172165.
- ^ "Entrez Gene: 5'-3' exoribonuclease 1".
Further reading
- Bashkirov VI, Scherthan H, Solinger JA, Buerstedde JM, Heyer WD (February 1997). "A mouse cytoplasmic exoribonuclease (mXRN1p) with preference for G4 tetraplex substrates". The Journal of Cell Biology. 136 (4): 761–73. PMID 9049243.
- Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (December 2002). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci". RNA. 8 (12): 1489–501. PMID 12515382.
- Braun JE, Truffault V, Boland A, Huntzinger E, Chang CT, Haas G, Weichenrieder O, Coles M, Izaurralde E (December 2012). "A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation". Nature Structural & Molecular Biology. 19 (12): 1324–31. S2CID 1134057.
- Li Y, Masaki T, Yamane D, McGivern DR, Lemon SM (January 2013). "Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication". Proceedings of the National Academy of Sciences of the United States of America. 110 (5): 1881–6. PMID 23248316.
- Li Y, Yamane D, Lemon SM (May 2015). "Dissecting the roles of the 5' exoribonucleases Xrn1 and Xrn2 in restricting hepatitis C virus replication". Journal of Virology. 89 (9): 4857–65. PMID 25673723.
- Burgess HM, Mohr I (March 2015). "Cellular 5'-3' mRNA exonuclease Xrn1 controls double-stranded RNA accumulation and anti-viral responses". Cell Host & Microbe. 17 (3): 332–44. PMID 25766294.
- Ding M, Lin B, Li T, Liu Y, Li Y, Zhou X, Miao M, Gu J, Pan H, Yang F, Li T, Liu XY, Li R (April 2015). "A dual yet opposite growth-regulating function of miR-204 and its target XRN1 in prostate adenocarcinoma cells and neuroendocrine-like prostate cancer cells". Oncotarget. 6 (10): 7686–700. PMID 25797256.
- Blasco-Moreno B, de Campos-Mata L, Böttcher R, García-Martínez J, Jungfleisch J, Nedialkova DD, Chattopadhyay S, Gas ME, Oliva B, Pérez-Ortín JE, Leidel SA, Choder M, Díez J (March 2019). "The exonuclease Xrn1 activates transcription and translation of mRNAs encoding membrane proteins". Nature Communications. 21 (10): 1298. PMID 30899024.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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