YAF2

YAF2
	Gene ontology
Molecular function	protein binding; metal ion binding; transcription coactivator activity; transcription corepressor activity;
Cellular component	nucleus; cytosol; nucleoplasm;
Biological process	positive regulation of transcription, DNA-templated; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of G0 to G1 transition;
	Sources:Amigo / QuickGO

Ensembl


ENSG00000015153


n/a

UniProt


Q8IY57


n/a

RefSeq (mRNA)

NM_001012424 NM_001190977 NM_001190979 NM_001190980 NM_005748
NM_001320080


n/a

RefSeq (protein)


NP_001177906 NP_001177908 NP_001177909 NP_001307009 NP_005739


n/a

Location (UCSC)

Chr 12: 42.16 – 42.24 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

YY1-associated factor 2 is a protein that in humans is encoded by the YAF2 gene.^[3]^[4]

The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1.^[4]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000015153 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
PMID 9016636
.

^ ^a ^b "Entrez Gene: YAF2 YY1 associated factor 2".

Further reading

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48.
S2CID 7827573
.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7.
PMID 15489334
.

Mädge B, Geisen C, Möröy T, Schwab M (2003). "Yaf2 inhibits Myc biological function". Cancer Lett. 193 (2): 171–6.
PMID 12706874
.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
PMID 12477932
.

Ogawa H, Ishiguro K, Gaubatz S, et al. (2002). "A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells". Science. 296 (5570): 1132–6.
S2CID 34863978
.

Sawa C, Yoshikawa T, Matsuda-Suzuki F, et al. (2002). "YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors". J. Biol. Chem. 277 (25): 22484–90.
PMID 11953439
.

Bannasch D, Mädge B, Schwab M (2001). "Functional interaction of Yaf2 with the central region of MycN". Oncogene. 20 (41): 5913–9.
S2CID 33486505
.

External links

YAF2 human gene location in the UCSC Genome Browser.

YAF2 human gene details in the UCSC Genome Browser.

v
t
e
PDB gallery

2d9g: Solution structure of the zf-RanBP domain of YY1-associated factor 2

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.
v
t
e

Retrieved from "https://en.wikipedia.org/w/index.php?title=YAF2&oldid=1204859020"

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000015153 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9016636-3] PMID 9016636
.

[entrez-4] "Entrez Gene: YAF2 YY1 associated factor 2".

[2]

[3]

[4]