ZGN-1061

ZGN-1061

Names
Preferred IUPAC name [(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl] 3-(2-morpholin-4-ylethyl)azetidine-1-carboxylate
Other names ZGN-1061, Aclimostat
Identifiers
CAS Number	2082752-83-6
3D model ( JSmol )	Interactive image
ChEMBL	ChEMBL4297651
ChemSpider	81368488
DrugBank	DB16079
PubChem CID	126573394
UNII	X150A3JK8R
InChI InChI=1S/C26H42N2O6/c1-18(2)5-6-21-25(3,34-21)23-22(30-4)20(7-9-26(23)17-32-26)33-24(29)28-15-19(16-28)8-10-27-11-13-31-14-12-27/h5,19-23H,6-17H2,1-4H3/t20-,21-,22-,23-,25+,26+/m1/s1 Key: QJWJPMLDQYEPPW-AUKZVGPFSA-N
SMILES CC(=CC[C@@H]1[C@@](O1)(C)[C@H]2[C@@H]([C@@H](CC[C@]23CO3)OC(=O)N4CC(C4)CCN5CCOCC5)OC)C
Properties
Chemical formula	C26H42N2O6
Molar mass	478.630 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

ZGN-1061 is an experimental drug that was developed by Zafgen for treatment of obesity and type 2 diabetes. It has a similar mechanism of action as the discontinued drug Beloranib but was considered safer; however, its development was also halted because of safety concerns.^[1][2][3]

References