ZIC1
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Location (UCSC) | Chr 3: 147.39 – 147.51 Mb | Chr 9: 91.24 – 91.25 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
ZIC1 is a member of the Zinc finger of the cerebellum (ZIC) protein family.[5][6]
ZIC1 is classified as a ZIC protein due to conservation of the five C2H2 zinc fingers, which enables the protein to interact with DNA and proteins. ZIC1 is found in close genomic configuration in another member of this protein family, ZIC4. Correct function of these proteins is critical for early development, and as such mutations of the genes encoding these proteins is known to result in various congenital defects. For example, if function of both ZIC1 and ZIC4 is lost (which can occur via an interstitial deletion due to their adjacent location) then this may result in the Dandy–Walker malformation.[7]
Interactions
ZIC1 has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000152977 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032368 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 22964024.
- ^ "Entrez Gene: ZIC1 Zic family member 1 (odd-paired homolog, Drosophila)".
- PMID 15338008.
- ^ PMID 11238441.
Further reading
- Houtmeyers R, Souopgui J, Tejpar S, Arkell R (2013). "The ZIC gene family encodes multi-functional proteins essential for patterning and morphogenesis". Cell Mol Life Sci. 70 (20): 3791–811. S2CID 8660667.
- Bagutti C, Forro G, Ferralli J, et al. (2004). "The intracellular domain of teneurin-2 has a nuclear function and represses zic-1-mediated transcription". J. Cell Sci. 116 (Pt 14): 2957–66. S2CID 30713.
- Pourebrahim R, Van Dam K, Bauters M, et al. (2007). "ZIC1 gene expression is controlled by DNA and histone methylation in mesenchymal proliferations". FEBS Lett. 581 (26): 5122–6. S2CID 25349004.