4'-Aminopropiophenone
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Names | |
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Preferred IUPAC name
1-(4-Aminophenyl)propan-1-one | |
Other names
1-(4-Aminophenyl)-1-propanone
para-Aminopropiophenone PAPP | |
Identifiers | |
3D model (
JSmol ) |
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ChemSpider | |
ECHA InfoCard
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100.000.675 |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C9H11NO | |
Molar mass | 149.193 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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4'-Aminopropiophenone (para-aminopropiophenone or PAPP) is a
The toxicity of PAPP is derived from its action on circulating
PAPP was first assessed at the Denver Wildlife Research Centre for its potential as a predator control agent in the United States in the early 1980s yet was not developed into a practical technology.[3] From the 1990s scientists based at the then Victorian Institute of Animal Science (Australia) were the first to demonstrate that PAPP could be formulated as a rapid acting and humane means of feral cat and exotic red fox control.[4]
Improved animal welfare outcomes and the existence of an antidote to treat accidental poisoning was an attractive feature of the agent given that the humaneness of the most commonly used poison (sodium fluoroacetate or '1080') is equivocal and no antidote exists for treating accidental 1080 poisoning. Due to the short duration after consumption before death it is critical the antidote be administered as soon as possible. The only antidote treatment that has been shown to work reliably to date is by intravenous (IV) administration.[5]
Researchers also discovered that the delivery of PAPP in feral cat baits within a specialised capsule, which exploits the unique dentition and feeding strategies of feral cats, could greatly limit the exposure of non-target animals to PAPP even if they consume a bait.[6] This became a significant feature adopted in the development of a feral cat bait[7] that became known as 'Curiosity'
Initially collaborating with scientists in Victoria,
References
- ^ Propiophenone, 4'-amino- at cameochemicals.noaa.gov.
- ^ Elaine C. Murphy; Charles T. Eason; Steve Hix; Duncan B. Macmorran (2007). "Developing a New Toxin for Potential Control of Feral Cats, Stoats, and Wild Dogs in New Zealand" (PDF). In G. W. Witmer; W. C. Pitt; K. A. Fagerstone (eds.). Managing Vertebrate Invasive Species: Proceedings of an International Symposium. Fort Collins, CO: USDA/APHIS Wildlife Services, National Wildlife Research Center. Archived from the original (PDF) on 2008-09-23.
- S2CID 26981555.
- ^ "Marks, C.A., Gigliotti, F., Busana, F., Johnston, M., Lindeman, M.(2004) Fox control using a para-aminopropiophenone formulation with the M-44 ejector. Animal Welfare v. 13, no. 4". agris.fao.org. Retrieved 2015-10-13.
- ^ "News".
- ^ Marks, C.A., Johnston, M.J., Fisher, P.M., Pontin, K. & Shaw, M.J. (2006) Differential particle size ingestion: promoting target-specific baiting of feral cats. Journal of Wildlife Management, 70, 1119-1124.
- doi:10.1071/AM07009.
- .
- ^ Shapiro, L.; Eason, C.T.; Murphy, E.; Dilks, P.; Hix, S.; Ogilvie, S.C.; MacMorran, D. (2010). "Para-aminopropiophenone (PAPP) research, development, registration, and application for humane predator control in New Zealand". In R.M. Timm; K.A. Fagerstone (eds.). Proc. 24th Vertebrate Pest Conference. pp. 108–114.
- ^ Denny, Elizabeth; Dickman, Christopher (2010). Review of cat ecology and management strategies in Australia (PDF). p. 40. Archived from the original (PDF) on 2013-10-01. Retrieved 2012-10-11.
- ^ Eason, C.T., Miller, A., MacMorran, D.B. & Murphy, E.C. (2014) Toxicology and ecotoxicology of para-aminopropiophenone (PAPP)–a new predator control tool for stoats and feral cats in New Zealand. New Zealand Journal of Ecology, 38, 177-188.