ADB-PINACA

Edit links
Source: Wikipedia, the free encyclopedia.
ADB-PINACA
Legal status
Legal status
Identifiers
  • N-(1-Amino-3,3-dimethyl-1-oxo-2-butanyl)-1-pentyl-1H-indazole-3-carboxamide
JSmol)
  • CCCCCN1C2=CC=CC=C2C(=N1)C(=O)NC(C(=O)N)C(C)(C)C
  • InChI=1S/C19H28N4O2/c1-5-6-9-12-23-14-11-8-7-10-13(14)15(22-23)18(25)21-16(17(20)24)19(2,3)4/h7-8,10-11,16H,5-6,9,12H2,1-4H3,(H2,20,24)(H,21,25)
  • Key:FWTARAXQGJRQKN-UHFFFAOYSA-N

ADB-PINACA is a

CB2 receptor with EC50 values of 0.52 nM and 0.88 nM respectively.[1][2] Like MDMB-FUBINACA, this compound incorporates the unnatural amino acid tert-leucine
.

Side effects

ADB-PINACA has been linked to multiple hospitalizations and deaths due to its use.[3][4][5]

Metabolism

Nineteen ADB-PINACA major metabolites were identified in several incubations with cryopreserved human hepatocytes. Major metabolic reactions included pentyl hydroxylation, hydroxylation followed by oxidation (ketone formation), and glucuronidation.[6]

Legality

ADB-PINACA is listed in the Fifth Schedule of the Misuse of Drugs Act (MDA) and therefore illegal in Singapore as of May 2015.[7]

In the United States, it is a

Schedule I controlled substance.[8] but its 5'-bromo analog ADB-5'Br-PINACA
is not as of October 20th, 2023.

As of October 2015 ADB-PINACA is a controlled substance in China.[9]

See also

References

  1. PMID 26134475
    .
  2. ^ "ADB-PINACA". Forendex. Archived from the original on 2014-07-14. Retrieved 2014-07-09.
  3. ^ "CDC: 221 sickened by synthetic pot in Colorado". USA Today. December 12, 2013.
  4. PMID 25726258
    .
  5. PMID 26154784
    .
  6. PMID 28302730
    .
  7. ^ "CNB NEWS RELEASE". Central Narcotics Bureau (CNB). 30 April 2015. Archived from the original on 15 July 2015. Retrieved 24 July 2015.
  8. PMID 24605391
    .
  9. ^ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Archived from the original on 1 October 2015. Retrieved 1 October 2015.
Retrieved from "https://en.wikipedia.org/w/index.php?title=ADB-PINACA&oldid=1206679388"