5F-AMB

5F-AMB
Legal status
Legal status	BR: Class F2 (Prohibited psychotropics); CA: Schedule II; DE: Anlage II (Authorized trade only, not prescriptible); UK: Class B; US: Schedule I; UN: Psychotropic Schedule II; Illegal in China, Japan, Sweden, Singapore,;
Identifiers
	IUPAC name Methyl (2S)-2-{[1-(5-fluoropentyl)-1H-indazol-3-yl]formamido}-3-methylbutanoate;
JSmol)	Interactive image;
	SMILES O=C(N[C@H](C(OC)=O)C(C)C)C1=NN(CCCCCF)C2=C1C=CC=C2;
	InChI InChI=1S/C19H26FN3O3/c1-13(2)16(19(25)26-3)21-18(24)17-14-9-5-6-10-15(14)23(22-17)12-8-4-7-11-20/h5-6,9-10,13,16H,4,7-8,11-12H2,1-3H3,(H,21,24)/t16-/m0/s1; Key:SAFXSUZMRLTBMM-INIZCTEOSA-N;

5F-AMB (also known as 5F-MMB-PINACA and 5F-AMB-PINACA) is an

synthetic cannabis products. It was first identified in Japan in early 2014.^[3]^[4]

Although only very little pharmacological information about 5F-AMB itself exists,

CB₁ receptor (K_I = 0.7 nM).^[6]^[7]

Side effects

5F-AMB intoxication caused one fatality on its own,[8] another through ketoacidosis in combination with AB-CHMINACA, AB-FUBINACA, AM-2201, 5F-APINACA, EAM-2201, JWH-018, JWH-122, MAM-2201, STS-135 and THJ-2201 and another fatality in combination with AB-CHMINACA and Diphenidine.^[9]^[10]

Legality

In the United States, 5F-AMB is a Schedule I controlled substance.^[11]

5F-AMB is an Anlage II controlled substance in Germany as of May 2015.^[12]

Sweden's public health agency suggested classifying 5F-AMB as hazardous substance on November 10, 2014.^[13]

The state of Louisiana banned 5F-AMB through an emergency rule after it was detected in a synthetic cannabinoids product called "Kali Berry 2" on 3 June 2014.^[14]

5F-AMB is controlled by the Fifth Schedule of the Misuse of Drugs Act (MDA) in Singapore as of May 2015.^[15]

5F-AMB was also scheduled in Japan on July 25, 2014.^[16]

As of October 2015 5F-AMB is a controlled substance in China.^[17]

In December 2019, the

UNODC announced scheduling recommendations placing 5F-MMB-PINACA as a Schedule II controlled research chemical.^[18]

References

^ Anvisa (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-07-25). Archived from the original on 2023-08-27. Retrieved 2023-08-27.
^ "5-Fluoro-AMB". Cayman Chemical. Retrieved 22 June 2015.
S2CID 11873421
.

S2CID 31838655
.

PMID 27003044
.

^ WO 2009106980, Buchler IP, Hayes MJ, Hegde SG, Hockerman SL, Jones DE, Kortum SW, Rico JG, Tenbrink RL, Wu LL, "Indazole derivatives", published 3 September 2009, assigned to Pfizer Inc.

PMID 27421060
.

PMID 27017174
.

PMID 26363623
.

S2CID 11884184
.

^ "Schedules of Controlled Substances: Temporary Placement of Six Synthetic Cannabinoids (5F-ADB, 5F-AMB, 5F-APINACA, ADB-FUBINACA, MDMB-CHMICA and MDMB-FUBINACA) Into Schedule I". Drug Enforcement Administration. Archived from the original on 2019-10-17. Retrieved 2017-03-17.

^ "Gesetz über den Verkehr mit Betäubungsmitteln (Betäubungsmittelgesetz - BtMG) Anlage II (zu § 1 Abs. 1) (verkehrsfähige, aber nicht verschreibungsfähige Betäubungsmittel)" [German Narcotics Act (Narcotic Drugs Act - BtMG) Annex II (to Section 1 (1)) (narcotics that can be marketed but not prescribed)] (in German). Retrieved 22 June 2015.

^ "Cannabinoider föreslås bli klassade som hälsofarlig vara" [Cannabinoids are proposed to be classified as dangerous to health] (in Swedish). Folkhälsomyndigheten. Retrieved 29 June 2015.

^ "DHH Adds Two New Synthetic Marijuana Compounds to Banned List". Louisiana Department of Health and Hospitals. 3 June 2014. Archived from the original on 18 September 2015. Retrieved 22 July 2015.

^ "CNB NEWS RELEASE". Central Narcotics Bureau (CNB). 30 April 2015. Archived from the original on 15 July 2015. Retrieved 24 July 2015.

^ "指定薬物一覧" [List of Designated Drugs] (PDF) (in Japanese). Ministry of Health, Labour and Welfare.

^ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" [On the issuance of non-pharmaceutical narcotic drugs and psychotropic substances listed in the notice] (in Chinese). China Food and Drug Administration. 27 September 2015. Archived from the original on 1 October 2015. Retrieved 1 October 2015.

^ "December 2019 – WHO: World Health Organization recommends 12 NPS for scheduling".

Retrieved from "https://en.wikipedia.org/w/index.php?title=5F-AMB&oldid=1212496052"

[1] Anvisa (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-07-25). Archived from the original on 2023-08-27. Retrieved 2023-08-27.

[2] "5-Fluoro-AMB". Cayman Chemical. Retrieved 22 June 2015.

[3] S2CID 11873421
.

[Shevyrin_2015-4] S2CID 31838655
.

[5] PMID 27003044
.

[6] WO 2009106980, Buchler IP, Hayes MJ, Hegde SG, Hockerman SL, Jones DE, Kortum SW, Rico JG, Tenbrink RL, Wu LL, "Indazole derivatives", published 3 September 2009, assigned to Pfizer Inc.

[7] PMID 27421060
.

[8] PMID 27017174
.

[9] PMID 26363623
.

[10] S2CID 11884184
.

[11] "Schedules of Controlled Substances: Temporary Placement of Six Synthetic Cannabinoids (5F-ADB, 5F-AMB, 5F-APINACA, ADB-FUBINACA, MDMB-CHMICA and MDMB-FUBINACA) Into Schedule I". Drug Enforcement Administration. Archived from the original on 2019-10-17. Retrieved 2017-03-17.

[12] "Gesetz über den Verkehr mit Betäubungsmitteln (Betäubungsmittelgesetz - BtMG) Anlage II (zu § 1 Abs. 1) (verkehrsfähige, aber nicht verschreibungsfähige Betäubungsmittel)" [German Narcotics Act (Narcotic Drugs Act - BtMG) Annex II (to Section 1 (1)) (narcotics that can be marketed but not prescribed)] (in German). Retrieved 22 June 2015.

[13] "Cannabinoider föreslås bli klassade som hälsofarlig vara" [Cannabinoids are proposed to be classified as dangerous to health] (in Swedish). Folkhälsomyndigheten. Retrieved 29 June 2015.

[14] "DHH Adds Two New Synthetic Marijuana Compounds to Banned List". Louisiana Department of Health and Hospitals. 3 June 2014. Archived from the original on 18 September 2015. Retrieved 22 July 2015.

[15] "CNB NEWS RELEASE". Central Narcotics Bureau (CNB). 30 April 2015. Archived from the original on 15 July 2015. Retrieved 24 July 2015.

[16] "指定薬物一覧" [List of Designated Drugs] (PDF) (in Japanese). Ministry of Health, Labour and Welfare.

[17] "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" [On the issuance of non-pharmaceutical narcotic drugs and psychotropic substances listed in the notice] (in Chinese). China Food and Drug Administration. 27 September 2015. Archived from the original on 1 October 2015. Retrieved 1 October 2015.

[18] "December 2019 – WHO: World Health Organization recommends 12 NPS for scheduling".

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Side effects

Legality

See also

References