AKAP11
| AKAP11 | |||
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Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| UniProt |
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| RefSeq (mRNA) | |||||||||
| RefSeq (protein) |
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| Location (UCSC) | Chr 13: 42.27 – 42.32 Mb | Chr 14: 78.73 – 78.77 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
A-kinase anchor protein 11 is an enzyme that in humans is encoded by the AKAP11 gene.[5][6][7]
Function
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function.[7]
Interactions
AKAP11 has been shown to
interact
with:
- GSK3B,[8]
- PPP1CA,[8][9]
- PRKAR2A,[6][8][10]
- PRKAR2B.[11]
- VAPB.[12] Binding is via a FFAT motif in the N-terminal portion of AKAP11, similar to that found in AKAP3. [13]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000023516 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022016 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 9734811.
- ^ PMID 8621616.
- ^ a b "Entrez Gene: AKAP11 A kinase (PRKA) anchor protein 11".
- ^ PMID 12147701.
- PMID 10209101.
- PMID 12672969.
- PMID 10864471.
- PMID 26186194.
- PMID 22276202.
External links
- Human AKAP11 genome location and AKAP11 gene details page in the UCSC Genome Browser.
Further reading
- Lester LB, Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases". Recent Prog. Horm. Res. 52: 409–29, discussion 429–30. PMID 9238861.
- Michel JJ, Scott JD (2002). "AKAP mediated signal transduction". Annu. Rev. Pharmacol. Toxicol. 42: 235–57. PMID 11807172.
- Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. PMID 12168954.
- Schillace RV, Scott JD (1999). "Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220". Curr. Biol. 9 (6): 321–4. PMID 10209101.
- Reinton N, Collas P, Haugen TB, Skâlhegg BS, Hansson V, Jahnsen T, Taskén K (2000). "Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis". Dev. Biol. 223 (1): 194–204. PMID 10864471.
- Schillace RV, Voltz JW, Sim AT, Shenolikar S, Scott JD (2001). "Multiple interactions within the AKAP220 signaling complex contribute to protein phosphatase 1 regulation". J. Biol. Chem. 276 (15): 12128–34. PMID 11152471.
- Schillace RV, Andrews SF, Liberty GA, Davey MP, Carr DW (2002). "Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes". J. Immunol. 168 (4): 1590–9. PMID 11823486.
- Tanji C, Yamamoto H, Yorioka N, Kohno N, Kikuchi K, Kikuchi A (2002). "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta". J. Biol. Chem. 277 (40): 36955–61. PMID 12147701.
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. PMID 17353931.
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