PPP1CA
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| Location (UCSC) | Chr 11: 67.4 – 67.42 Mb | Chr 19: 4.24 – 4.25 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit is an enzyme that in humans is encoded by the PPP1CA gene.
Function
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.[5]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
Nicotine Activity on Dopaminergic Neurons edit
- ^ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".
Interactions
PPP1CA has been shown to
interact
with:
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000172531 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040385 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: PPP1CA protein phosphatase 1, catalytic subunit, alpha isoform".
- PMID 12147701.
- S2CID 9188320.
- ^ PMID 12115603.
- PMID 12438214.
- PMID 11101529.
- ^ PMID 10637318.
- S2CID 6153394.
- PMID 12393858.
- PMID 12925532.
- PMID 12724406.
- ^ PMID 12016208.
- PMID 11564868.
- PMID 12788942.
- PMID 10194355.
- PMID 12138106.
Further reading
- Cohen PT (2002). "Protein phosphatase 1--targeted in many directions". J. Cell Sci. 115 (Pt 2): 241–56. PMID 11839776.
- Barker HM, Jones TA, da Cruz e Silva EF, Spurr NK, Sheer D, Cohen PT (1990). "Localization of the gene encoding a type I protein phosphatase catalytic subunit to human chromosome band 11q13". Genomics. 7 (2): 159–66. PMID 2161401.
- Carrey EA, Campbell DG, Hardie DG (1986). "Phosphorylation and activation of hamster carbamyl phosphate synthetase II by cAMP-dependent protein kinase. A novel mechanism for regulation of pyrimidine nucleotide biosynthesis". EMBO J. 4 (13B): 3735–42. PMID 4092695.
- Saadat M, Mizuno Y, Kikuchi K, Yoshida MC (1995). "Comparative mapping of the gene encoding the catalytic subunit of protein phosphatase type 1 alpha (PPP1CA) to human, rat, and mouse chromosomes". Cytogenet. Cell Genet. 70 (1–2): 55–7. PMID 7736790.
- Durfee T, Becherer K, Chen PL, Yeh SH, Yang Y, Kilburn AE, Lee WH, Elledge SJ (1993). "The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit". Genes Dev. 7 (4): 555–69. PMID 8384581.
- Song Q, Khanna KK, Lu H, Lavin MF (1993). "Cloning and characterization of a human protein phosphatase 1-encoding cDNA". Gene. 129 (2): 291–5. PMID 8392016.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.
- Kwon YG, Huang HB, Desdouits F, Girault JA, Greengard P, Nairn AC (1997). "Characterization of the interaction between DARPP-32 and protein phosphatase 1 (PP-1): DARPP-32 peptides antagonize the interaction of PP-1 with binding proteins". Proc. Natl. Acad. Sci. U.S.A. 94 (8): 3536–41. PMID 9108011.
- Colbran RJ, Bass MA, McNeill RB, Bollen M, Zhao S, Wadzinski BE, Strack S (1997). "Association of brain protein phosphatase 1 with cytoskeletal targeting/regulatory subunits". J. Neurochem. 69 (3): 920–9. S2CID 34789662.
- Allen PB, Kwon YG, Nairn AC, Greengard P (1998). "Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit". J. Biol. Chem. 273 (7): 4089–95. PMID 9461602.
- Zhang J, Zhang L, Zhao S, PMID 9843442.
- Neumann J, Maas R, Bokník P, Jones LR, Zimmermann N, Scholz H (1999). "Pharmacological characterization of protein phosphatase activities in preparations from failing human hearts". J. Pharmacol. Exp. Ther. 289 (1): 188–93. PMID 10087003.
- Schillace RV, Scott JD (1999). "Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220". Curr. Biol. 9 (6): 321–4. S2CID 9188320.
- Takahashi M, Shibata H, Shimakawa M, Miyamoto M, Mukai H, Ono Y (1999). "Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus". J. Biol. Chem. 274 (24): 17267–74. PMID 10358086.
- McAvoy T, Allen PB, Obaishi H, Nakanishi H, Takai Y, Greengard P, Nairn AC, Hemmings HC (1999). "Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation". Biochemistry. 38 (39): 12943–9. PMID 10504266.
- Yoshida K, Watanabe M, Kato H, Dutta A, Sugano S (1999). "BH-protocadherin-c, a member of the cadherin superfamily, interacts with protein phosphatase 1 alpha through its intracellular domain". FEBS Lett. 460 (1): 93–8. S2CID 24377126.
- Yang J, Hurley TD, DePaoli-Roach AA (2000). "Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif". J. Biol. Chem. 275 (30): 22635–44. PMID 10807923.
- Ayllón V, Martínez-A C, García A, Cayla X, Rebollo A (2000). "Protein phosphatase 1alpha is a Ras-activated Bad phosphatase that regulates interleukin-2 deprivation-induced apoptosis". EMBO J. 19 (10): 2237–46. PMID 10811615.
- Boudrez A, Beullens M, Groenen P, Van Eynde A, Vulsteke V, Jagiello I, Murray M, Krainer AR, Stalmans W, Bollen M (2000). "NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry". J. Biol. Chem. 275 (33): 25411–7. PMID 10827081.
- Helps NR, Luo X, Barker HM, Cohen PT (2001). "NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1". Biochem. J. 349 (Pt 2): 509–18. PMID 10880350.
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