AT-121

AT-121
Legal status
Legal status	Investigational;
Identifiers
	IUPAC name 3-oxo-1'-(4-propan-2-ylcyclohexyl)-2-[2-(sulfamoylamino)ethyl]spiro[1H-isoquinoline-4,4'-piperidine];
JSmol)	Interactive image;
	SMILES CC(C)[C@H]1CC[C@H](CC1)N1CCC2(CC1)C(=O)N(CCNS(N)(=O)=O)CC1=CC=CC=C21;

AT-121 is an experimental analgesic. It was designed to be bifunctional, acting as an agonist at both the μ-opioid receptor and the nociceptin receptor.^[1] The interaction with the nociceptin receptor is expected to block the abuse and dependence-related side effects that are typical of opioids.^[2] A study in nonhuman primates found that AT-121 has morphine-like analgesic effects, but suppressed the addictive effects.^[1]^[3]