ATP5D
| ATP5F1D | |||
|---|---|---|---|
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 19: 1.24 – 1.24 Mb | Chr 10: 80.14 – 80.15 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
ATP synthase subunit delta, mitochondrial, also known as ATP synthase F1 subunit delta or F-ATPase delta subunit is an
inner membrane during oxidative phosphorylation.[8]
Structure
The ATP5F1D gene is located on the
mitochondrial inner membrane by the F0 unit.[11]
Function
This gene encodes a subunit of the mitochondrial
proton channel linked by a central and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F1 is coupled by a rotary mechanism of the central stalk subunits to proton transport. The encoded protein is a part of the complex F1 domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to the hydrolysis of ATP in three separate catalytic sites on the beta subunits.[5][6]
Clinical significance
Mutations of ATP5F1D have been associated with childhood
amyotrophic lateral sclerosis (ALS) pathogenesis.[13]
Interactions
Among the two components, CF1 - the catalytic core - and CF0 - the membrane proton channel of the F-type ATPase, ATP5F1D is associated with the catalytic core. The catalytic core is composed of five different subunits including alpha, beta, gamma, delta, and epsilon subunits. The protein has additional interactions with
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000099624 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003072 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c
"ATP5F1D - ATP synthase subunit delta, mitochondrial precursor - Homo sapiens (Human) - ATP5F1D gene & protein". Retrieved 2018-08-07.
This article incorporates text available under the CC BY 4.0 license.
- ^ a b c
"UniProt: the universal protein knowledgebase". Nucleic Acids Research. 45 (D1): D158–D169. January 2017. PMID 27899622.
- PMID 1531933.
- ^ a b c d "Entrez Gene: ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit".
This article incorporates text from this source, which is in the public domain.
- ^
Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, et al. (October 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research. 113 (9): 1043–53. PMID 23965338.
- ^ "ATP synthase subunit delta, mitochondrial". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB).[permanent dead link]
- PMID 7599212.
- PMID 29478781.
- PMID 27899032.
- ^
Mick DU, Dennerlein S, Wiese H, Reinhold R, Pacheu-Grau D, Lorenzi I, Sasarman F, Weraarpachai W, Shoubridge EA, Warscheid B, Rehling P (2012). "MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation". Cell. 151 (7): 1528–41. PMID 23260140.
Further reading
- Yoshida M, Muneyuki E, Hisabori T (September 2001). "ATP synthase--a marvellous rotary engine of the cell". Nature Reviews. Molecular Cell Biology. 2 (9): 669–77. S2CID 3926411.
- Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C, Sanchez JC, Tissot JD, Bjellqvist B, Vargas R (December 1992). "Human liver protein map: a reference database established by microsequencing and gel comparison". Electrophoresis. 13 (12): 992–1001. S2CID 23518983.
- Yasuda R, Noji H, Kinosita K, Yoshida M (June 1998). "F1-ATPase is a highly efficient molecular motor that rotates with discrete 120 degree steps". Cell. 93 (7): 1117–24. S2CID 14106130.
- Wang H, Oster G (November 1998). "Energy transduction in the F1 motor of ATP synthase". Nature. 396 (6708): 279–82. S2CID 4424498.
- Cross RL (January 2004). "Molecular motors: turning the ATP motor". Nature. 427 (6973): 407–8. S2CID 52819856.
- Itoh H, Takahashi A, Adachi K, Noji H, Yasuda R, Yoshida M, Kinosita K (January 2004). "Mechanically driven ATP synthesis by F1-ATPase". Nature. 427 (6973): 465–8. S2CID 4428646.
External links
- Human ATP5D genome location and ATP5D gene details page in the UCSC Genome Browser.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.