Anti-apoptotic Ras signalling cascade

Source: Wikipedia, the free encyclopedia.

The Anti-apoptotic Ras signaling cascade is an intracellular signal transduction cascade that involves the

Ras protein and inhibits apoptosis. It is the target of the cancer drug gefitinib
.

It may refer to the

AKT pathway.[1][2][3]

It may refer to the MAPK/ERK pathway which involves ras and can affect apoptosis.[4][5]

The anti-apoptotic STAT pathway does not involve Ras.

See also

  • Ras subfamily

References

  1. S2CID 34389318
    .
  2. ^ http://genesdev.cshlp.org/content/11/6/701.abstract "The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal" 1997
  3. S2CID 36511428
    .
  4. ^ http://cancerres.aacrjournals.org/cgi/content/abstract/67/21/10343 "Suppression of PTEN Expression Is Essential for Antiapoptosis and Cellular Transformation by Oncogenic Ras" 2007
  5. ^ http://www.aacrmeetingabstracts.org/cgi/content/abstract/2005/1/972-b "Pathways potentiated by oncogenic Ras to modulate apoptosis induced by anticancer agent FR901228 " 2005
  • [1] Diagram of ras onwards.