Antonín Holý
Antonín Holý | |
|---|---|
Academy of Sciences of the Czech Republic (1992 – 2002) | |
| Doctoral students | Michal Hocek |
Antonín Holý (1 September 1936 – 16 July 2012) was a pioneering
AIDS.[2] Antonín Holý is the author of more than 450 papers, 400 scientific discoveries and holds 60 patents.[3][4][5] With more than 400 discoveries to his credit, his work has affected millions of people with viral diseases such as HIV/AIDS and hepatitis B and many other viral diseases.[6] In 2008 he received an Honorary Professorship at the University of Manchester's School of Chemistry.[7]
Scientific career
Born in
nucleic acids
. In 1987 he became chief of the Department of Nucleic Acid Chemistry and from 1994 to 2002 he was head of the IOCB.
Since 1976 he had collaborated on the development of new antiretroviral drugs with
His key contribution is the synthesis of
Tenofovir
. Together, these drugs have made an dramatic impact for the treatment of HIV. In particular, Truvada has shown exceptionally useful in preventing HIV transmission and thus has not only helped countless HIV patients, but has in fact prevented countless other healthy individuals from contracting the disease in the first place.
In 2006 the US biopharmaceutical company Gilead Sciences, under the direction of Tomáš Cihlář,[10] and the Institute of Organic Chemistry and Biochemistry (IOCB) of the Academy of Sciences of the Czech Republic jointly established a new research center, oriented to the development of new preparations.[8] Gilead promised the IOCB a $1.1 million donation, to fund its operations and research for 5 years.[8]
Several antiretroviral drugs based on Holý's discoveries have been licensed. In 1996,
Truvada, a combination of Viread and emtricitabine, was approved in 2006 for use in the USA.[11]
Death
Holý had retired a year before his death and died of an unspecified cause, aged 75, on 16 July 2012. A statement from the IOCB called his death "an immense loss".Truvada for treating HIV.[6]
Awards and honours
- 1984 State Prize for Chemistry (Acyklická analoga nukleosidů a nukleotidů)[4]
- 1998 Honor plaque: Nucleic Acids Chemistry journal[4]
- 1999 Hanuš's Medal of the
- 2001 Descartes Prize of the European Union;[3][4][9] The Medal of Merit of the Czech Republic (Za zásluhy) I. degree
- 2002 Elion Award of International Society for Antiviral Research;[4] State Medal "Pour merit"[4]
- 2003 Honorary membership in the Rega Institute for Medical Research, Catholic University of Leuven, Belgium.
- 2004 Award Praemium Bohemiae;[14] Medal of the Czech Academy of Sciences: De scientia et humanitate optime meritis
- 2005 Honorary doctorate of the Ghent University (Belgium); The Medal of Merit of the Faculty of Science at the Charles University in Prague.
- 2006 Member of the European Academy of Sciences and Arts (Salzburg)
- 2006 Honorary doctorate of the Institute of Chemical Technology in Prague
- 2007 State Prize "Czech Head" (Česká hlava)
- 2008 Honorary Professorship at the School of Chemistry, University of Manchester
- 2009 Honorary doctorate of the University of South Bohemia in České Budějovice
- 2011 Silver memorial medal of the Senate of the Parliament of the Czech Republic
- 2012 Silver medal of the City of Prague
See also
References
- ^ "ICD 2009 - The most significant contemporary discoveries". 2009-05-08. Archived from the original on 2009-05-08. Retrieved 2022-07-20.
- ^ "Faces of the Presidency". EU2009.cz. Archived from the original on 19 January 2009. Retrieved 8 January 2009.
- ^ a b "Czech Chemistry: A Tradition of Innovation and Prosperity". Association for Foreign Investment. Archived from the original on 18 July 2011. Retrieved 8 January 2009.
- ^ a b c d e f g h "UOCHB A.Holy". 2009-04-14. Archived from the original on 2009-04-14. Retrieved 2022-07-20.
- ^ "Personalities of today - Czech republic". 2008-12-20. Archived from the original on 2008-12-20. Retrieved 2022-07-20.
- ^ a b "Groundbreaking chemist Antonín Holý dies at 75". Radio Prague. 17 July 2012. Retrieved 17 July 2012.
- ^ "Antonín Holý received a Honorary Professorship of School of Chemistry". Academic bulletin. Archived from the original on 27 January 2010. Retrieved 8 January 2009.
- ^ a b c "Gilead Sciences and the Institute of Organic Chemistry and Biochemistry (IOCB) Establish New Academic Research Centre in Prague; Donation by Gilead Honors Leadership of Dr. Antonin Holy in Antiviral Drug Discovery and Development". new.gilead.com. Retrieved 2020-01-08.
- ^ a b "Veda a umenia súvisia". legacy.blisty.cz (in Czech). Retrieved 2022-07-20.
- ^ Czech News Agency, "Did Czech scientists create the cure for coronavirus?", Aktuálně.cz, February 05, 2020.
- ^ "Truvada (tenofovir + emtricitabine)". AIDSmeds.com. Archived from the original on 10 January 2009. Retrieved 8 January 2009.
- Mladá fronta DNES(in Czech). iDnes. 17 July 2012. Retrieved 17 July 2012.
- ^ "HIV drug developer Antonin Holy dies". CBC.ca. Retrieved 17 July 2012.
- ^ "Praemium Bohemiae podruhé" (in Czech). Academic Bulletin. Archived from the original on 10 March 2009. Retrieved 8 January 2009.
External links
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